2.1.1.357: [histone H3]-lysine36 N-dimethyltransferase

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For detailed information about [histone H3]-lysine36 N-dimethyltransferase, go to the full flat file.

Word Map on EC 2.1.1.357

2.1.1.357

myeloma

chromatin

wolf-hirschhorn

transposase

setmar

end-joining

t4;14-positive

decatenation

trithorax

synthesis

Reaction

2 S-adenosyl-L-methionine +

= 2 S-adenosyl-L-homocysteine +

a [histone H3]-N6,N6-dimethyl-L-lysine36

Synonyms

Ash1L, EC 2.1.1.43, H3K36 KMTase, H3K36 methyltransferase, H3K36-specific methyltransferase, histone H3 lysine 36 methyltransferase, KMT3B, KMT3C, Metnase, MMSET, NSD1, NSD2, NSD3, nuclear receptor SET domain containing protein 2, nuclear receptor-binding SET domain protein 2, SET, SETD2, SETMAR, Smyd2, Whsc1, WHSC1L1

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.357 [histone H3]-lysine36 N-dimethyltransferase

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Results	in table
64	AA Sequence
1	Application
4	Cloned(Commentary)
3	Crystallization (Commentary)
656	Disease/ Diagnostics
11	General Information
2	IC50 Value
5	Inhibitors
4	KM Value [mM]
1	Metals/Ions
28	Natural Substrates/ Products (Substrates)
15	Organism
2	Pathway
23	PDB ID
2	Purification (Commentary)
3	Reaction
13	Reference
21	Source Tissue
34	Substrates and Products (Substrate)
55	Synonyms
1	Systematic Name
2	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.1.1.357 - [histone H3]-lysine36 N-dimethyltransferase

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A-893

inhibitor of SMYD2

AZ505

inhibitor of SMYD2

histone H3.3 K36M mutant protein

Homo sapiens

inhibits the H3K36 methyltransferases MMSET and SETD2

755538

histone H3K36M-containing polynucleosome

LLY-507

inhibitor of SMYD2