2.1.1.346: U6 snRNA m6A methyltransferase

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For detailed information about U6 snRNA m6A methyltransferase, go to the full flat file.

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Synonyms

m6A methyltransferase, m6A RNA methyltransferase, methyltransferase like protein 16, methyltransferase-like protein 16, METTL16, N6-methyladenosine (m6A) methyltransferase, RNA m6A methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.346 U6 snRNA m6A methyltransferase

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423	AA Sequence
2	Cloned(Commentary)
2	Crystallization (Commentary)
95	Disease/ Diagnostics
6	General Information
3	Localization
11	Natural Substrates/ Products (Substrates)
9	Organism
9	PDB ID
1	Purification (Commentary)
1	Reaction
9	Reference
5	Source Tissue
16	Substrates and Products (Substrate)
3	Subunits
17	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.1.1.346 - U6 snRNA m6A methyltransferase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:adenine in U6 snRNA methyltransferase

This enzyme, found in vertebrates, methylates a specific adenine in a hairpin structure of snRNA. The effects of the binding of the methyltransferase to its substrate is important for the regulation of the activity of an isoform of EC 2.5.1.6, methionine adenosyltransferase, that produces S-adenosyl-L-methionine [1,2]. The enzyme also binds (and maybe methylates) the lncRNAs XIST and MALAT1 as well as a number of pre-mRNAs at specific positions often found in the intronic regions [2].