2.1.1.346: U6 snRNA m6A methyltransferase
This is an abbreviated version!
For detailed information about U6 snRNA m6A methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.346
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2.1.1.346
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mettl3
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alkbh5
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methyltransferases
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writer
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epitranscriptome
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n6-adenosine
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ythdf3
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erasers
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igf2bp1
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demethylases
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malat1
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rbm15b
- 2.1.1.346
- mettl3
- alkbh5
- methyltransferases
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writer
-
epitranscriptome
-
n6-adenosine
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ythdf3
-
erasers
-
igf2bp1
- demethylases
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malat1
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rbm15b
Reaction
Synonyms
m6A methyltransferase, m6A RNA methyltransferase, methyltransferase like protein 16, methyltransferase-like protein 16, METTL16, N6-methyladenosine (m6A) methyltransferase, RNA m6A methyltransferase
ECTree
2.1.1.346 U6 snRNA m6A methyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.1.1.346 - U6 snRNA m6A methyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + adenine in MAT2A hairpin 1
S-adenosyl-L-homocysteine + N6-methyladenine in MAT2A hairpin 1
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?
S-adenosyl-L-methionine + adenine in U6 lncRNA
S-adenosyl-L-homocysteine + N6-methyladenine in U6 lncRNA
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?
S-adenosyl-L-methionine + adenine in U6 ncRNA
S-adenosyl-L-homocysteine + N6-methyladenine in U6 ncRNA
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?
S-adenosyl-L-methionine + adenine in U6 pre-mRNA
S-adenosyl-L-homocysteine + N6-methyladenine in U6 pre-mRNA
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?
S-adenosyl-L-methionine + adenine in U6 snRNA
S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
S-adenosyl-L-methionine + adenine-43 in U6 snRNA
S-adenosyl-L-homocysteine + N6-methyladenine-43 in U6 snRNA
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additional information
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U6 snRNA lacking the stem-loop near the 5' end is as efficient a substrate as the full-length U6 snRNA. U6 snRNA(41-106) is not methylated efficiently. Deletion of 19 nucleotides of the 3' end stem-loop structure (U6 snRNA(1-88)) reduces the efficiency to 20-45% of the wild-type, and U6 snRNA(1-67) does not serves as substrate at all
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S-adenosyl-L-methionine + adenine in U6 snRNA
S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
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?
S-adenosyl-L-methionine + adenine in U6 snRNA
S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
the enzyme is responsible for N6-methylation of A43 of the U6 snRNA
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?
S-adenosyl-L-methionine + adenine in U6 snRNA
S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
regulation of Mat2a mRNA by Mettl16 is essential for mouse embryonic development
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S-adenosyl-L-methionine + adenine in U6 snRNA
S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
the enzyme methylates U6 spliceosomal RNA and interacts with the 3'-terminal RNA triple helix of MALAT1 (metastasis-associated lung adenocarcinoma transcript 1). Full-length METTL16 binds to the MALAT1 RNA triple helix, but monomeric METTL16_291 does not
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S-adenosyl-L-methionine + adenine in U6 snRNA
S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
generation of a comprehensive atlas of methylome uniquely mediated by methyltransferase. METTL16 indirectly impacts manifold methylation targets beyond its consensus target motif (UACm6AGAGAA)
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?
S-adenosyl-L-methionine + adenine in U6 snRNA
S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
when presented with a random pool of RNAs, METTL16 selects for methylation-structured RNAs where the critical adenosine is present in a bulge
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?
S-adenosyl-L-methionine + adenine in U6 snRNA
S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
regulation of Mat2a mRNA by Mettl16 is essential for mouse embryonic development
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?
S-adenosyl-L-methionine + adenine in U6 snRNA
S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
when presented with a random pool of RNAs, METTL16 selects for methylation-structured RNAs where the critical adenosine is present in a bulge
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?
