2.1.1.346: U6 snRNA m6A methyltransferase

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For detailed information about U6 snRNA m6A methyltransferase, go to the full flat file.

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Synonyms

m6A methyltransferase, m6A RNA methyltransferase, methyltransferase like protein 16, methyltransferase-like protein 16, METTL16, N6-methyladenosine (m6A) methyltransferase, RNA m6A methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.346 U6 snRNA m6A methyltransferase

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Results	in table
423	AA Sequence
2	Cloned(Commentary)
2	Crystallization (Commentary)
95	Disease/ Diagnostics
6	General Information
3	Localization
11	Natural Substrates/ Products (Substrates)
9	Organism
9	PDB ID
1	Purification (Commentary)
1	Reaction
9	Reference
5	Source Tissue
16	Substrates and Products (Substrate)
3	Subunits
17	Synonyms
1	Systematic Name

General Information

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General Information on EC 2.1.1.346 - U6 snRNA m6A methyltransferase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

2 entries

metabolism

Homo sapiens

Q86W50

the enzyme is required for induction of MAT2A splicing

744644

physiological function

3 entries

malfunction

Homo sapiens

Q86W50

METTL16 depletion decreases MAT2A expression, resulting in reduced intracellular S-adenosyl-L-methionine, a key substrate required for RNA methylation. Loss of METTL16 can result in a transcriptome-wide loss of m6A methylation beyond sites directly methylated by METTL16

757751

malfunction

Mus musculus

Q9CQG2

mouse 16-cell embryos lacking Mettl16 display reduced mRNA levels of its methylation target, the S-adenosyl-L-methionine synthetase Mat2a

757652

physiological function

Homo sapiens

Q86W50

regulation of Mat2a mRNA by Mettl16 is essential for mouse embryonic development

757652

physiological function

Mus musculus

Q9CQG2

regulation of Mat2a mRNA by Mettl16 is essential for mouse embryonic development

757652

physiological function

Homo sapiens

Q86W50

siRNA knockdown of METTL16 results in expression changes of a few mRNA targets suggesting that METTL16 may play a role in regulating gene expression

758186