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2.1.1.346: U6 snRNA m6A methyltransferase

This is an abbreviated version!
For detailed information about U6 snRNA m6A methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.346

Reaction

S-adenosyl-L-methionine
+
adenine in U6 snRNA
=
S-adenosyl-L-homocysteine
 +
N6-methyladenine in U6 snRNA

Synonyms

m6A methyltransferase, m6A RNA methyltransferase, methyltransferase like protein 16, methyltransferase-like protein 16, METTL16, N6-methyladenosine (m6A) methyltransferase, RNA m6A methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.346 U6 snRNA m6A methyltransferase

Crystallization

Crystallization on EC 2.1.1.346 - U6 snRNA m6A methyltransferase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure of the methyltransferase domain from human METTL16
hanging-drop method at 19°C. Crystal structures of the N-terminal methyltransferase domain (residues 1-291) of human METTL16 (METTL16_291): an apo structure at 1.9 A resolution and a post-catalytic S-adenosylhomocysteine bound complex at 2.1 A resolution. The structures revealed a highly conserved Rossmann fold that is characteristic of class I S-adenosylmethionine-dependent methyltransferases and a large, positively charged groove. This groove likely represents the RNA-binding site and it includes structural elements unique to METTL16