2.1.1.148: thymidylate synthase (FAD)

This is an abbreviated version!
For detailed information about thymidylate synthase (FAD), go to the full flat file.

Word Map on EC 2.1.1.148

2.1.1.148

medicine

tuberculosis

dtmp

synthases

thymidine

dihydrofolate

maritima

bursaria

2'-deoxyuridine

paramecium

folate-dependent

chlorella

5-substituted

virus-1

ch2h4folate

2'-deoxythymidine-5'-monophosphate

flavoenzyme

drug development

Reaction

Synonyms

A674R, complementing thymidylate synthase, FDTS, flavin dependent thymidylate synthase, flavin-dependent thymidylate synthase, flavin-dependent thymidylate synthase X, flavin-dependent TS, Thy1, thymidylate synthase 1, thymidylate synthase complementing protein, thymidylate synthase ThyX, thymidylate synthase X, ThyX, thyX-encoded thymidylate synthase, TSCP, TTHA1096

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.148 thymidylate synthase (FAD)

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
14	Activating Compound
10362	AA Sequence
53	Application
1	CAS Registry Number
14	Cloned(Commentary)
123	Cofactor
16	Crystallization (Commentary)
1	Expression
2	General Information
8	IC50 Value
33	Inhibitors
10	Ki Value [mM]
17	KM Value [mM]
1	Metals/Ions
10	Molecular Weight [Da]
47	Natural Substrates/ Products (Substrates)
152	Organism
6	Pathway
137	PDB ID
1	pH Optimum
1	pH Range
1	Posttranslational Modification
44	Protein Variants
12	Purification (Commentary)
2	Reaction
5	Reaction Type
116	Reference
2	Storage Stability
123	Substrates and Products (Substrate)
20	Subunits
121	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
7	Temperature Stability [°C]
7	Turnover Number [1/s]

IC50 Value

print visible entries

print all entries

IC50 Value on EC 2.1.1.148 - thymidylate synthase (FAD)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to IC50 Value Search

0.00172

4-(3-(3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)propanoyl)-N-phenylpiperazine-1-carboxamide

Mycobacterium tuberculosis

P9WG57

pH 7.5, temperature not specified in the publication

756483

4-[3-(3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)propanoyl]-N-phenylpiperazine-1-carboxamide

Mycobacterium tuberculosis

P9WG57

pH 7.5, temperature not specified in the publication

756483

0.016 - 0.048

5,10-methylenetetrahydrofolate

2 entries

0.0083 - 0.00832

5-undecyloxymethyl-2'-deoxyuridine 5'-monophosphate

2 entries

0.00069

N-methyl-2-[4-[3-(3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)propanoyl]piperazin-1-yl]-N-phenylacetamide

Mycobacterium tuberculosis

P9WG57

pH 7.5, temperature not specified in the publication

756483

0.00088

N-[1-[3-(3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)propanoyl]piperidin-4-yl]-N'-phenylurea

Mycobacterium tuberculosis

P9WG57

pH 7.5, temperature not specified in the publication

756483