2.1.1.148: thymidylate synthase (FAD)

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For detailed information about thymidylate synthase (FAD), go to the full flat file.

Reaction

Synonyms

A674R, complementing thymidylate synthase, FDTS, flavin dependent thymidylate synthase, flavin-dependent thymidylate synthase, flavin-dependent thymidylate synthase X, flavin-dependent TS, Thy1, thymidylate synthase 1, thymidylate synthase complementing protein, thymidylate synthase ThyX, thymidylate synthase X, ThyX, thyX-encoded thymidylate synthase, TSCP, TTHA1096

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.148 thymidylate synthase (FAD)

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Results	in table
14	Activating Compound
10362	AA Sequence
53	Application
1	CAS Registry Number
14	Cloned(Commentary)
123	Cofactor
16	Crystallization (Commentary)
1	Expression
2	General Information
8	IC50 Value
33	Inhibitors
10	Ki Value [mM]
17	KM Value [mM]
1	Metals/Ions
10	Molecular Weight [Da]
47	Natural Substrates/ Products (Substrates)
152	Organism
6	Pathway
137	PDB ID
1	pH Optimum
1	pH Range
1	Posttranslational Modification
44	Protein Variants
12	Purification (Commentary)
2	Reaction
5	Reaction Type
116	Reference
2	Storage Stability
123	Substrates and Products (Substrate)
20	Subunits
121	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
7	Temperature Stability [°C]
7	Turnover Number [1/s]

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Cloned on EC 2.1.1.148 - thymidylate synthase (FAD)

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Thermotoga maritima

Q9WYT0

637235, 734346

complemetation of Escherichia coli thyA deletion mutant, transformants are able to grow in the absence of thymidine under oxygen limited conditions

Campylobacter jejuni

-

637233

complemetation of Escherichia coli, transformants are able to grow in the absence of thymidine

Helicobacter pylori

Q9ZJ93

637232

complemetation of Escherichia coli, transformants are unable to grow in the absence of thymidine

Pyrococcus abyssi

Q9UZ51

637232

complemetation of Haloferax volcanii thyA deletion mutant, transformants are able to grow in the absence of thymidine

Halobacterium salinarum

-

637233

expressed in Escherichia coli M15 cells

Helicobacter pylori

Q5UVJ4

720992

expression in Escherichia coli

2 entries

histidine-tagged Mycobacterium tuberculosis ThyX is overexpressed from BL21-DE3 pLysS Escherichia coli

Mycobacterium tuberculosis

-

694812

I65M/L175M double mutant expressed in Escherichia coli BL21 (DE3) pLysS strain as C-terminal His6-tagged protein

Mycobacterium tuberculosis

P9WG57

681384

into the pET24d vector, overexpressed in Escherichia coli chi2913 strain, plasmid containing the I65M/L175M double mutant expressed in Escherichia coli BL21 (DE3) pLysS strain

Mycobacterium tuberculosis

-

681375

overexpression of the recombinant C-terminal His6-tagged protein in Escherichia coli strain BL21(DE3)

Pyrococcus furiosus

Q8U3C9

678023

wild-type and mutant ThyX proteins expressed in either Escherichia coli DH5alpha (deltathyA) or BL21

Paramecium bursaria Chlorella virus-1

-

680675

expression in Escherichia coli

Paramecium bursaria Chlorella virus-1

-

659429

expression in Escherichia coli

Helicobacter pylori

O26061

757894