2.1.1.148: thymidylate synthase (FAD)

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For detailed information about thymidylate synthase (FAD), go to the full flat file.

Word Map on EC 2.1.1.148

2.1.1.148

medicine

tuberculosis

dtmp

synthases

thymidine

dihydrofolate

maritima

bursaria

2'-deoxyuridine

paramecium

folate-dependent

chlorella

5-substituted

virus-1

ch2h4folate

2'-deoxythymidine-5'-monophosphate

flavoenzyme

drug development

Reaction

Synonyms

A674R, complementing thymidylate synthase, FDTS, flavin dependent thymidylate synthase, flavin-dependent thymidylate synthase, flavin-dependent thymidylate synthase X, flavin-dependent TS, Thy1, thymidylate synthase 1, thymidylate synthase complementing protein, thymidylate synthase ThyX, thymidylate synthase X, ThyX, thyX-encoded thymidylate synthase, TSCP, TTHA1096

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.148 thymidylate synthase (FAD)

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Results	in table
14	Activating Compound
10362	AA Sequence
53	Application
1	CAS Registry Number
14	Cloned(Commentary)
123	Cofactor
16	Crystallization (Commentary)
1	Expression
2	General Information
8	IC50 Value
33	Inhibitors
10	Ki Value [mM]
17	KM Value [mM]
1	Metals/Ions
10	Molecular Weight [Da]
47	Natural Substrates/ Products (Substrates)
152	Organism
6	Pathway
137	PDB ID
1	pH Optimum
1	pH Range
1	Posttranslational Modification
44	Protein Variants
12	Purification (Commentary)
2	Reaction
5	Reaction Type
116	Reference
2	Storage Stability
123	Substrates and Products (Substrate)
20	Subunits
121	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
7	Temperature Stability [°C]
7	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 2.1.1.148 - thymidylate synthase (FAD)

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104000

Mycobacterium tuberculosis

gel filtration

111000

gel filtration

23800

SDS-PAGE

25000

4 * 25000, SDS-PAGE

25020

4 * 25020, calculated from amino acid sequence

720992

25066

Helicobacter pylori

Q5UVJ4

4 * 25066, MALDI TOF mass spectrometry

720992

26000

Paramecium bursaria Chlorella virus-1

x * 26000, SDS-PAGE

659429

29000

Pyrococcus furiosus

Q8U3C9

x * 29000, sequence analysis, x * 29000, SDS-PAGE

31000

SDS-PAGE

31500

calculated from DNA sequence

637232