Literature summary for 2.1.1.148 extracted from

Alexandrova, L.A.; Chekhov, V.O.; Shmalenyuk, E.R.; Kochetkov, S.N.; El-Asrar, R.A.; Herdewijn, P.
Synthesis and evaluation of C-5 modified 2-deoxyuridine monophosphates as inhibitors of M. tuberculosis thymidylate synthase (2015), Bioorg. Med. Chem., 23, 7131-7137 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular docking of inhibitor 5-undecyloxymethyl-2'-deoxyuridine 5'-monophosphate. The inhibitor and substrate dUMP share the same binding mode	Mycobacterium tuberculosis

Inhibitors

Inhibitors	Comment	Organism	Structure
5-undecyloxymethyl-2'-deoxyuridine 5'-monophosphate	compound lacks activity against isoform ThyA, EC 2.1.1.45	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WG57	-	-
Mycobacterium tuberculosis ATCC 25618	P9WG57	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00832	-	pH 7.5, 23°	Mycobacterium tuberculosis	5-undecyloxymethyl-2'-deoxyuridine 5'-monophosphate

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Release 2023.1 (January 2023)