Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Helicobacter pylori |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(furan-2-yl)-3-hydroxynaphthalene-1,4-dione | inhibits the NADPH oxidation and 2'-deoxythymidine-5'-monophosphate-forming activities of ThyX in vitro | Helicobacter pylori | |
2-hydroxy-3-(4-methoxyphenyl)naphthalene-1,4-dione | inhibits the NADPH oxidation and 2'-deoxythymidine-5'-monophosphate-forming activities of ThyX in vitro | Helicobacter pylori | |
2-hydroxy-3-propylnaphthalene-1,4-dione | inhibits the NADPH oxidation and 2'-deoxythymidine-5'-monophosphate-forming activities of ThyX in vitro, significant decrease of 1.22 log (17fold) in the colonization loads with Helicobacter pylori of mice treated with the molecule | Helicobacter pylori | |
2-[4-fluoro-3-(trifluoromethyl)phenyl]-3-hydroxynaphthalene-1,4-dione | inhibits the NADPH oxidation and 2'-deoxythymidine-5'-monophosphate-forming activities of ThyX in vitro | Helicobacter pylori |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Helicobacter pylori | O26061 | - |
- |
Helicobacter pylori 26695 | O26061 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
ThyX | - |
Helicobacter pylori |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000028 | - |
2-(furan-2-yl)-3-hydroxynaphthalene-1,4-dione | pH 8.0, 37°C | Helicobacter pylori | |
0.000258 | - |
2-hydroxy-3-propylnaphthalene-1,4-dione | pH 8.0, 37°C | Helicobacter pylori | |
0.000367 | - |
2-hydroxy-3-(4-methoxyphenyl)naphthalene-1,4-dione | pH 8.0, 37°C | Helicobacter pylori | |
0.001 | - |
2-[4-fluoro-3-(trifluoromethyl)phenyl]-3-hydroxynaphthalene-1,4-dione | pH 8.0, 37°C | Helicobacter pylori |