Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.99.66: [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase

This is an abbreviated version!
For detailed information about [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase, go to the full flat file.

Word Map on EC 1.14.99.66

Reaction

a [histone H3]-N6,N6-dimethyl-L-lysine4
+ 2 acceptor + 2 H2O =
a [histone H3]-L-lysine4
 + 2 formaldehyde + 2 reduced acceptor

Synonyms

amine oxidase flavin-containing domain 1, amine-oxidase flavin-containing domain 1, AOF1, AOF2, BHC110, BHC110/LSD1, CG9088, demethylase LSD1, dJARID1/Lid, H3K4 demethylase, H3K4me2 demethylase, H3K4me2/1 histone demethylase, histone demethylase, histone H3 K4 demethylase, histone H3 lysine 4 demethylase, histone H3K4 demethylase, histone lysine-specific demethylase 1, Jarid1, KDM1, KDM1A, KDM1B, KIAA0601, LD40310, Lid, LSD1, LSD1 demethylase, LSD1/KDM1, LSD1/KDM1A, LSD2, lysine demethylase 1B, lysine specific demethylase 1, lysine-specific demethylase 1, lysine-specific demethylase 1A, lysine-specific demethylase 2, lysine-specific demethylase-1, lysine-specific histone demethylase, lysine-specific histone demethylase 1, lysine-specific histone demethylase 1A, lysine-specific histone demethylase 1B, lysinespecific demethylase 1, More, SPR-5

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.99 Miscellaneous
                1.14.99.66 [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase

Turnover Number

Turnover Number on EC 1.14.99.66 - [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.199
H3K4me2 (1-21 aa) peptide
recombinant enzyme LSD1, pH 7.5, 25°C
-
0.1 - 0.159
H3K4me2 1-21 peptide
-
0.0043
[histone H3 peptide 21mer P16A]-N6-methyl-L-lysine4
-
pH 8.0, 25°C, recombinant wild-type LSD2
-
0.0222
[histone H3 peptide 21mer]-N6,N6-dimethyl-L-lysine4-dimethyl-L-lysine9
-
pH 8.0, 25°C, recombinant wild-type LSD2
-
0.0046 - 0.033
[histone H3 peptide 21mer]-N6-methyl-L-lysine4
-
0.0058
[histone H3 peptide 21mer]-N6-methyl-L-lysine4-acetyl-L-lysine9
-
pH 8.0, 25°C, recombinant wild-type LSD2
-
0.005
[histone H3 peptide 21mer]-N6-methyl-L-lysine4-methyl-L-arginine17
-
pH 8.0, 25°C, recombinant wild-type LSD2
-
0.004
[histone H3 peptide 21mer]-N6-methyl-L-lysine4-methyl-L-lysine9
-
pH 8.0, 25°C, recombinant wild-type LSD2
-
0.0068
[histone H3 peptide 30mer]-N6-methyl-L-lysine4
-
pH 8.0, 25°C, recombinant wild-type LSD2
-
0.011
[histone H3]-N6,N6-dimethyl-L-lysine4
pH 8.0, 22°C, recombinant LSD1
0.051
[histone H3]-N6,N6-L-dimethyllysine21
pH 7.5, 25°C
-
0.1 - 0.159
[histone H3]-N6,N6-L-dimethyllysine4-1-21
-
0.008
[histone H3]-N6-methyl-L-lysine4
pH 8.0, 22°C, recombinant LSD1