1.14.99.66: [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase

This is an abbreviated version!
For detailed information about [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase, go to the full flat file.

Reaction

Synonyms

amine oxidase flavin-containing domain 1, amine-oxidase flavin-containing domain 1, AOF1, AOF2, BHC110, BHC110/LSD1, CG9088, demethylase LSD1, dJARID1/Lid, H3K4 demethylase, H3K4me2 demethylase, H3K4me2/1 histone demethylase, histone demethylase, histone H3 K4 demethylase, histone H3 lysine 4 demethylase, histone H3K4 demethylase, histone lysine-specific demethylase 1, Jarid1, KDM1, KDM1A, KDM1B, KIAA0601, LD40310, Lid, LSD1, LSD1 demethylase, LSD1/KDM1, LSD1/KDM1A, LSD2, lysine demethylase 1B, lysine specific demethylase 1, lysine-specific demethylase 1, lysine-specific demethylase 1A, lysine-specific demethylase 2, lysine-specific demethylase-1, lysine-specific histone demethylase, lysine-specific histone demethylase 1, lysine-specific histone demethylase 1A, lysine-specific histone demethylase 1B, lysinespecific demethylase 1, More, SPR-5

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.99 Miscellaneous

                1.14.99.66 [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase

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Results	in table
6	Activating Compound
9	AA Sequence
3	Application
20	Cloned(Commentary)
32	Cofactor
11	Crystallization (Commentary)
292	Disease/ Diagnostics
2	Expression
86	General Information
9	IC50 Value
139	Inhibitors
7	kcat/KM [mM/s]
26	Ki Value [mM]
23	KM Value [mM]
47	Localization
3	Metals/Ions
3	Molecular Weight [Da]
97	Natural Substrates/ Products (Substrates)
123	Organism
20	PDB ID
9	pH Optimum
1	pH Range
1	Posttranslational Modification
21	Protein Variants
10	Purification (Commentary)
3	Reaction
64	Reference
86	Source Tissue
155	Substrates and Products (Substrate)
5	Subunits
161	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
18	Turnover Number [1/s]

KI Value

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KI Value on EC 1.14.99.66 - [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.5

(2-hydroxyacetyl)-L-alanyl-L-arginyl-L-threonyl-L-methionyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucine

Homo sapiens

O60341

pH 7.5, 25°C

744494

0.17

(2-hydroxyacetyl)-L-arginyl-L-threonyl-L-methionyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucine

Homo sapiens

O60341

pH 7.5, 25°C

744494

0.0000189

histone H3

2 entries

-

0.00177

histone H3 1-21 peptide

Homo sapiens

O60341

pH 7.5, 25°C, recombinant enzyme

744347

-

0.00177

histone H3-1-21

Homo sapiens

O60341

pH 7.5, 25°C

744347

-

0.0156

L-alanyl-L-arginyl-L-threonyl-6-(aziridin-1-yl)norleucyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-L-alanine

Homo sapiens

O60341

pH and temperature not specified in the publication

753965

0.000098

L-alanyl-L-arginyl-L-threonyl-L-methionyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucine

Homo sapiens

O60341

pH 7.5, 25°C

744494

0.0043

L-alanyl-L-arginyl-L-threonyl-N6-(prop-2-yn-1-yl)lysyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-L-alanine

Homo sapiens

O60341

pH and temperature not specified in the publication

753965

0.5

L-arginyl-L-threonyl-L-methionyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucine

Homo sapiens

O60341

pH 7.5, 25°C

744494

0.0063

L-homoseryseryl-L-arginyl-L-threonyl-L-methionyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-(N6-(L-homoseryl))-L-lysine

Homo sapiens

O60341

pH 7.5, 25°C

744494

0.00003

L-seryl-L-arginyl-L-threonyl-L-methionyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucine

Homo sapiens

O60341

pH 7.5, 25°C

744494

0.5

N-(hydroxyacetyl)-L-alanyl-L-arginyl-L-threonyl-L-methionyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-N6-(hydroxyacetyl)-L-lysyl-L-glutaminyl-L-leucine

Homo sapiens

O60341

pH 7.5, 25°C

744494

0.5

N-(hydroxyacetyl)-L-alanyl-L-arginyl-L-threonyl-L-methionyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-N6-(hydroxyacetyl)-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucine

Homo sapiens

O60341

pH 7.5, 25°C

744494

0.0014

N2-L-alanyl-L-arginyl-L-threonyl-L-methionyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-N6-(2-hydroxyacetyl)-L-lysyl-L-glutaminyl-L-leucine

Homo sapiens

O60341

pH 7.5, 25°C

744494

0.0098

N2-L-alanyl-L-arginyl-L-threonyl-L-methionyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-N6-(2-hydroxyacetyl)-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucine

Homo sapiens

O60341

pH 7.5, 25°C

744494

0.00038

N2-L-seryl-L-arginyl-L-threonyl-L-methionyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-(N6-(L-seryl))-L-lysyl-L-glutaminyl-L-leucine

Homo sapiens

O60341

pH 7.5, 25°C

744494

0.00006

N2-L-seryl-L-arginyl-L-threonyl-L-methionyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-(N6-(L-seryl))-L-lysine-amide

Homo sapiens

O60341

pH 7.5, 25°C

744494

0.00029

N2-L-seryl-L-arginyl-L-threonyl-L-methionyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucyl-L-alanyl-L-threonyl-(N6-(L-seryl))-L-lysine-amide

Homo sapiens

O60341

pH 7.5, 25°C

744494

0.046

[histone H3 peptide 21mer]-L-arginine4

Mus musculus

-

pH 8.0, 25°C, recombinant wild-type LSD2

698910

-

0.002

[histone H3 peptide 21mer]-L-glutamine4

Mus musculus

-

pH 8.0, 25°C, recombinant wild-type LSD2

698910

-

0.033

[histone H3 peptide 21mer]-L-lysine4

Mus musculus

-

pH 8.0, 25°C, recombinant wild-type LSD2

698910

-

0.00015

[histone H3 peptide 21mer]-L-methionine4

Mus musculus

-

pH 8.0, 25°C, recombinant wild-type LSD2

698910

-

0.058

[histone H3 peptide 21mer]-N6,N6,N6-trimethyl-L-lysine4

Mus musculus

-

pH 8.0, 25°C, recombinant wild-type LSD2

698910

-

0.0066

[histone H3 peptide 21mer]-N6-methyl-L-lysine9

Mus musculus

-

pH 8.0, 25°C, recombinant wild-type LSD2

698910

-

additional information

additional information

Homo sapiens

O60341

inhibition kinetics, steady-state progress curves are obtained for the inactivation of LSD1

753965

-

0.0000189

histone H3

Homo sapiens

O60341

pH 7.5, 25°C

744347

-

0.0000189

histone H3

Homo sapiens

O60341

pH 7.5, 25°C, recombinant enzyme

744347

-