1.14.99.66: [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase

This is an abbreviated version!
For detailed information about [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase, go to the full flat file.

Reaction

Synonyms

amine oxidase flavin-containing domain 1, amine-oxidase flavin-containing domain 1, AOF1, AOF2, BHC110, BHC110/LSD1, CG9088, demethylase LSD1, dJARID1/Lid, H3K4 demethylase, H3K4me2 demethylase, H3K4me2/1 histone demethylase, histone demethylase, histone H3 K4 demethylase, histone H3 lysine 4 demethylase, histone H3K4 demethylase, histone lysine-specific demethylase 1, Jarid1, KDM1, KDM1A, KDM1B, KIAA0601, LD40310, Lid, LSD1, LSD1 demethylase, LSD1/KDM1, LSD1/KDM1A, LSD2, lysine demethylase 1B, lysine specific demethylase 1, lysine-specific demethylase 1, lysine-specific demethylase 1A, lysine-specific demethylase 2, lysine-specific demethylase-1, lysine-specific histone demethylase, lysine-specific histone demethylase 1, lysine-specific histone demethylase 1A, lysine-specific histone demethylase 1B, lysinespecific demethylase 1, More, SPR-5

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.99 Miscellaneous

                1.14.99.66 [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase

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Results	in table
6	Activating Compound
9	AA Sequence
3	Application
20	Cloned(Commentary)
32	Cofactor
11	Crystallization (Commentary)
292	Disease/ Diagnostics
2	Expression
86	General Information
9	IC50 Value
139	Inhibitors
7	kcat/KM [mM/s]
26	Ki Value [mM]
23	KM Value [mM]
47	Localization
3	Metals/Ions
3	Molecular Weight [Da]
97	Natural Substrates/ Products (Substrates)
123	Organism
20	PDB ID
9	pH Optimum
1	pH Range
1	Posttranslational Modification
21	Protein Variants
10	Purification (Commentary)
3	Reaction
64	Reference
86	Source Tissue
155	Substrates and Products (Substrate)
5	Subunits
161	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
18	Turnover Number [1/s]

KM Value

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KM Value on EC 1.14.99.66 - [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0026

H3K4me2 (1-21 aa) peptide

Homo sapiens

O60341

recombinant enzyme LSD1, pH 7.5, 25°C

752749

-

0.00446 - 0.00889

H3K4me2 1-21 peptide

3 entries

-

0.2

H3K4me2 peptide 3-21

Homo sapiens

O60341

pH not specified in the publication, 25°C

753965

-

0.195

O2

Homo sapiens

O60341

recombinant enzyme LSD1, pH 7.5, 25°C, with H3K4me2 (1-21 aa) peptide

752749

0.0125

[histone H3 peptide 21mer P16A]-N6-methyl-L-lysine4

Mus musculus

-

pH 8.0, 25°C, recombinant wild-type LSD2

698910

-

0.0066

[histone H3 peptide 21mer]-N6,N6-dimethyl-L-lysine4-dimethyl-L-lysine9

Mus musculus

-

pH 8.0, 25°C, recombinant wild-type LSD2

698910

-

0.0113 - 0.092

[histone H3 peptide 21mer]-N6-methyl-L-lysine4

2 entries

-

0.0705

[histone H3 peptide 21mer]-N6-methyl-L-lysine4-acetyl-L-lysine9

Mus musculus

-

pH 8.0, 25°C, recombinant wild-type LSD2

698910

-

0.0081

[histone H3 peptide 21mer]-N6-methyl-L-lysine4-methyl-L-arginine17

Mus musculus

-

pH 8.0, 25°C, recombinant wild-type LSD2

698910

-

0.009

[histone H3 peptide 21mer]-N6-methyl-L-lysine4-methyl-L-lysine9

Mus musculus

-

pH 8.0, 25°C, recombinant wild-type LSD2

698910

-

0.0051

[histone H3 peptide 30mer]-N6-methyl-L-lysine4

Mus musculus

-

pH 8.0, 25°C, recombinant wild-type LSD2

698910

-

0.0107

[histone H3]-N6,N6-dimethyl-L-lysine4

Arabidopsis thaliana

Q8VXV7

pH 8.0, 22°C, recombinant LSD1

696261

0.05

[histone H3]-N6,N6-L-dimethyllysine21

Homo sapiens

O60341

pH 7.5, 25°C

752748

-

0.00446 - 0.00889

[histone H3]-N6,N6-L-dimethyllysine4-1-21

3 entries

-

0.0089

[histone H3]-N6-methyl-L-lysine4

Arabidopsis thaliana

Q8VXV7

pH 8.0, 22°C, recombinant LSD1

696261

additional information

additional information

3 entries

-

0.00446

H3K4me2 1-21 peptide

Homo sapiens

O60341

pH 7.5, 25°C, recombinant N-terminally truncated KDM1A

744347

-

0.00814

H3K4me2 1-21 peptide

Homo sapiens

O60341

pH 7.5, 25°C, recombinant N-terminally truncated KDM1A-CoREST-C complex

744347

-

0.00889

H3K4me2 1-21 peptide

Homo sapiens

O60341

pH 7.5, 25°C, recombinant N-terminally truncated KDM1A-CoREST-Linker complex

744347

-

0.0113

[histone H3 peptide 21mer]-N6-methyl-L-lysine4

Mus musculus

-

pH 8.0, 25°C, recombinant wild-type LSD2

698910

-

0.092

[histone H3 peptide 21mer]-N6-methyl-L-lysine4

Mus musculus

-

pH 8.0, 25°C, recombinant wild-type LSD2

698910

-

0.00446

[histone H3]-N6,N6-L-dimethyllysine4-1-21

Homo sapiens

O60341

recombinant enzyme, pH 7.5, 25°C

744347

-

0.00814

[histone H3]-N6,N6-L-dimethyllysine4-1-21

Homo sapiens

O60341

recombinant enzyme, presence of activator CoREST, pH 7.5, 25°C

744347

-

0.00889

[histone H3]-N6,N6-L-dimethyllysine4-1-21

Homo sapiens

O60341

recombinant enzyme, presence of a protein corresponding to the linker region of activator CoREST, pH 7.5, 25°C

744347

-

additional information

additional information

Homo sapiens

O60341

dissociation constant for substrate H3K4me2 peptide 3-21 is 0.080 mM

753965

-

additional information

additional information

Homo sapiens

O60341

Michaelis-Menten steady-state kinetics of N-terminally truncated KDM1A and differential KDM1A/CoREST complexes using an H3K4me2 1-21 peptide substrate

744347

-

additional information

additional information

Homo sapiens

O60341

Michaelis-Menten steady-state kinetics, stopped-flow data, kinetic isotope effects at different pH values from pH 7.0-9.5, overview

752749

-