1.14.14.73: albendazole monooxygenase (sulfoxide-forming)
This is an abbreviated version!
For detailed information about albendazole monooxygenase (sulfoxide-forming), go to the full flat file.
Word Map on EC 1.14.14.73
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1.14.14.73
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arachidonic
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epoxyeicosatrienoic
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epoxygenase
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cardiovascular
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epoxide
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astemizole
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cyp2js
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eicosanoids
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cyp3a5
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cyp1b1
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o-demethylation
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ebastine
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vasodilatory
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terfenadine
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cyp4f2
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cyp4a11
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cis-epoxyeicosatrienoic
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epoxygenase-derived
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regioisomeric
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dihydroxyeicosatrienoic
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ms-ppoh
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dhets
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danazol
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14,15-epoxyeicosatrienoic
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20-hetes
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cyp27a1
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cyp-derived
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medicine
- 1.14.14.73
-
arachidonic
-
epoxyeicosatrienoic
- epoxygenase
- cardiovascular
- epoxide
- astemizole
-
cyp2js
-
eicosanoids
- cyp3a5
- cyp1b1
-
o-demethylation
- ebastine
-
vasodilatory
- terfenadine
- cyp4f2
- cyp4a11
-
cis-epoxyeicosatrienoic
-
epoxygenase-derived
-
regioisomeric
-
dihydroxyeicosatrienoic
-
ms-ppoh
-
dhets
- danazol
-
14,15-epoxyeicosatrienoic
- 20-hetes
- cyp27a1
-
cyp-derived
- medicine
Reaction
Synonyms
albendazole hydroxylase, albendazole sulfoxidase, BVMORj24, CYP1A2, CYP2J2, CYP3A4, cytochrome P450 2J2, MT1
ECTree
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Substrates Products
Substrates Products on EC 1.14.14.73 - albendazole monooxygenase (sulfoxide-forming)
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REACTION DIAGRAM
albendazole + [reduced NADPH-hemoprotein reductase] + O2
albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
amiodarone + [reduced NADPH-hemoprotein reductase] + O2
? + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
astemizole + [reduced NADPH-hemoprotein reductase] + O2
? + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
cyclosporin + [reduced NADPH-hemoprotein reductase] + O2
? + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
danazol + [reduced NADPH-hemoprotein reductase] + O2
? + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
fenbendazole + [reduced NADPH-hemoprotein reductase] + O2
fenbendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
mesoridazine + [reduced NADPH-hemoprotein reductase] + O2
? + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
thioridazine + [reduced NADPH-hemoprotein reductase] + O2
? + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
albendazole + [reduced NADPH-hemoprotein reductase] + O2
albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
albendazole + [reduced NADPH-hemoprotein reductase] + O2
albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
albendazole + [reduced NADPH-hemoprotein reductase] + O2
albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
albendazole + [reduced NADPH-hemoprotein reductase] + O2
albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
albendazole + [reduced NADPH-hemoprotein reductase] + O2
albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
albendazole + [reduced NADPH-hemoprotein reductase] + O2
albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
?
-
enzyme is able to modify antihistamine drugs such as albendazole, amiodarone, astemizole, thioridazine, mesoridazine, and danazol. The substrates vary in size and overall topology from relatively rigid structures (amiodarone) to larger complex structures (cyclosporine). CYP2J2 metabolism is more restrictive than that of YP3A4 and limited, in general, to a single site for large compounds
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-
?
additional information
?
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-
enzyme is able to modify antihistamine drugs such as albendazole, amiodarone, astemizole, thioridazine, mesoridazine, and danazol. The substrates vary in size and overall topology from relatively rigid structures (amiodarone) to larger complex structures (cyclosporine). CYP2J2 metabolism is more restrictive than that of YP3A4 and limited, in general, to a single site for large compounds
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?