1.14.14.73: albendazole monooxygenase (sulfoxide-forming)
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For detailed information about albendazole monooxygenase (sulfoxide-forming), go to the full flat file.
Word Map on EC 1.14.14.73
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1.14.14.73
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arachidonic
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epoxyeicosatrienoic
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epoxygenase
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cardiovascular
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epoxide
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astemizole
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cyp2js
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eicosanoids
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cyp3a5
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cyp1b1
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o-demethylation
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ebastine
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vasodilatory
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terfenadine
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cyp4f2
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cyp4a11
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cis-epoxyeicosatrienoic
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epoxygenase-derived
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regioisomeric
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dihydroxyeicosatrienoic
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ms-ppoh
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dhets
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danazol
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14,15-epoxyeicosatrienoic
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20-hetes
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cyp27a1
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cyp-derived
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medicine
- 1.14.14.73
-
arachidonic
-
epoxyeicosatrienoic
- epoxygenase
- cardiovascular
- epoxide
- astemizole
-
cyp2js
-
eicosanoids
- cyp3a5
- cyp1b1
-
o-demethylation
- ebastine
-
vasodilatory
- terfenadine
- cyp4f2
- cyp4a11
-
cis-epoxyeicosatrienoic
-
epoxygenase-derived
-
regioisomeric
-
dihydroxyeicosatrienoic
-
ms-ppoh
-
dhets
- danazol
-
14,15-epoxyeicosatrienoic
- 20-hetes
- cyp27a1
-
cyp-derived
- medicine
Reaction
Synonyms
albendazole hydroxylase, albendazole sulfoxidase, BVMORj24, CYP1A2, CYP2J2, CYP3A4, cytochrome P450 2J2, MT1
ECTree
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Application on EC 1.14.14.73 - albendazole monooxygenase (sulfoxide-forming)
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
medicine
enzyme is able to modify antihistamine drugs such as albendazole, amiodarone, astemizole, thioridazine, mesoridazine, and danazol with in vitro intrinsic clearance values ranging from 0.06 to 3.98 microl/min/pmol CYP2J2. Whereas isoform CYP3A4 commonly metabolizes compounds at multiple sites, CYP2J2 metabolism is more restrictive and limited, in general, to a single site for large compounds
