1.14.14.73: albendazole monooxygenase (sulfoxide-forming)
This is an abbreviated version!
For detailed information about albendazole monooxygenase (sulfoxide-forming), go to the full flat file.
Word Map on EC 1.14.14.73
-
1.14.14.73
-
arachidonic
-
epoxyeicosatrienoic
-
epoxygenase
-
cardiovascular
-
epoxide
-
astemizole
-
cyp2js
-
eicosanoids
-
cyp3a5
-
cyp1b1
-
o-demethylation
-
ebastine
-
vasodilatory
-
terfenadine
-
cyp4f2
-
cyp4a11
-
cis-epoxyeicosatrienoic
-
epoxygenase-derived
-
regioisomeric
-
dihydroxyeicosatrienoic
-
ms-ppoh
-
dhets
-
danazol
-
14,15-epoxyeicosatrienoic
-
20-hetes
-
cyp27a1
-
cyp-derived
-
medicine
- 1.14.14.73
-
arachidonic
-
epoxyeicosatrienoic
- epoxygenase
- cardiovascular
- epoxide
- astemizole
-
cyp2js
-
eicosanoids
- cyp3a5
- cyp1b1
-
o-demethylation
- ebastine
-
vasodilatory
- terfenadine
- cyp4f2
- cyp4a11
-
cis-epoxyeicosatrienoic
-
epoxygenase-derived
-
regioisomeric
-
dihydroxyeicosatrienoic
-
ms-ppoh
-
dhets
- danazol
-
14,15-epoxyeicosatrienoic
- 20-hetes
- cyp27a1
-
cyp-derived
- medicine
Reaction
Synonyms
albendazole hydroxylase, albendazole sulfoxidase, BVMORj24, CYP1A2, CYP2J2, CYP3A4, cytochrome P450 2J2, MT1
ECTree
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Reference on EC 1.14.14.73 - albendazole monooxygenase (sulfoxide-forming)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wu, Z.; Lee, D.; Joo, J.; Shin, J.; Kang, W.; Oh, S.; Lee, D.; Lee, S.; Yea, S.; Lee, H.; Lee, T.; Liu, K.
CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems
Antimicrob. Agents Chemother.
57
5448-5456
2013
Homo sapiens (P51589), Homo sapiens
Rawden, H.; Kokwaro, G.; Ward, S.; Edwards, G.
Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes
Br. J. Clin. Pharmacol.
49
313-322
2000
Homo sapiens (P08684)
Moroni, P.; Buronfosse, T.; Longin-Sauvageon, C.; Delatour, P.; Benoit, E.
Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes
Drug Metab. Dispos.
23
160-165
1995
Rattus norvegicus
Lee, C.; Neul, D.; Clouser-Roche, A.; Dalvie, D.; Wester, M.; Jiang, Y.; Jones III, J.; Freiwald, S.; Zientek, M.; Totah, R.
Identification of novel substrates for human cytochrome P450 2J2
Drug Metab. Dispos.
38
347-356
2010
Homo sapiens (P51589), Homo sapiens
Gul, T.; Krzek, M.; Permentier, H.; Fraaije, M.; Bischoff, R.
Microbial flavoprotein monooxygenases as mimics of mammalian flavin-containing monooxygenases for the enantioselective preparation of drug metabolites
Drug Metab. Dispos.
44
1270-1276
2016
Rhodococcus jostii, Thermothelomyces thermophilus
Souhaili-El Amri, H.; Mothe, O.; Totis, M.; Masson, C.; Batt, A.M.; Delatour, P.; Siest, G.
Albendazole sulfonation by rat liver cytochrome P-450c
J. Pharmacol. Exp. Ther.
246
758-764
1988
Rattus norvegicus
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