1.14.14.145: abieta-7,13-dien-18-ol hydroxylase

This is an abbreviated version!
For detailed information about abieta-7,13-dien-18-ol hydroxylase, go to the full flat file.

Reaction

Synonyms

abieta-7,13-dien-18-ol hydroxylase, abietadienol/abietadienal oxidase, CYP720B1, CyPA, CYPA1, CYPA2, CyPB, CYPC, CYPD, EC 1.14.13.109, PtAO

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.145 abieta-7,13-dien-18-ol hydroxylase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	Activating Compound
78	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
5	Cofactor
5	IC50 Value
6	Inhibitors
16	KM Value [mM]
5	Localization
8	Natural Substrates/ Products (Substrates)
12	Organism
3	Pathway
4	pH Optimum
2	pH Range
4	Reaction
11	Reference
5	Source Tissue
1	Specific Activity [micromol/min/mg]
24	Substrates and Products (Substrate)
19	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Systematic Name

print visible entries

print all entries

Systematic Name on EC 1.14.14.145 - abieta-7,13-dien-18-ol hydroxylase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Systematic Name Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SYSTEMATIC NAME

IUBMB Comments

abieta-7,13-dien-18-ol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (18-hydroxylating)

A cytochrome P-450 (heme-thiolate) protein. This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine) [1], and the gene encoding the enzyme has been identified in Pinus taeda (loblolly pine) [3]. The recombinant enzyme catalyses the oxidation of multiple diterpene alcohol and aldehydes, including levopimaradienol, isopimara-7,15-dienol, isopimara-7,15-dienal, dehydroabietadienol and dehydroabietadienal. It is not able to oxidize abietadiene.