1.14.14.145: abieta-7,13-dien-18-ol hydroxylase

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For detailed information about abieta-7,13-dien-18-ol hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.145

1.14.14.145

cyp1a1

diterpene

pinus

taeda

loblolly

picea

conifer

nadph-cytochrome

olefins

levopimaradiene

spruce

abietadiene

abietic

oleoresin

sitchensis

Reaction

Synonyms

abieta-7,13-dien-18-ol hydroxylase, abietadienol/abietadienal oxidase, CYP720B1, CyPA, CYPA1, CYPA2, CyPB, CYPC, CYPD, EC 1.14.13.109, PtAO

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.145 abieta-7,13-dien-18-ol hydroxylase

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Results	in table
1	Activating Compound
78	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
5	Cofactor
5	IC50 Value
6	Inhibitors
16	KM Value [mM]
5	Localization
8	Natural Substrates/ Products (Substrates)
12	Organism
3	Pathway
4	pH Optimum
2	pH Range
4	Reaction
11	Reference
5	Source Tissue
1	Specific Activity [micromol/min/mg]
24	Substrates and Products (Substrate)
19	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

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Reference on EC 1.14.14.145 - abieta-7,13-dien-18-ol hydroxylase

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666567

Ro, D.K.; Bohlmann, J.

Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): Functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1)

Phytochemistry

1572-1578

2006

Pinus taeda (Q50EK6), Pinus taeda

16497345

676795

Ro, D.K.; Arimura, G.; Lau, S.Y.; Piers, E.; Bohlmann, J.

Loblolly pine abietadienol/abietadienal oxidase PtAO (CYP720B1) is a multifunctional, multisubstrate cytochrome P450 monooxygenase

Proc. Natl. Acad. Sci. USA

102

8060-8065

2005

Pinus taeda, Pinus taeda (Q50EK3), Pinus taeda (Q50EK4), Pinus taeda (Q50EK5), Pinus taeda (Q50EK6), Picea sitchensis (Q50EK0), Picea sitchensis (Q50EK1)

15911762

690605

Funk, C.; Croteau, R.

Diterpenoid resin acid biosynthesis in conifers: characterization of two cytochrome P450-dependent monooxygenases and an aldehyde dehydrogenase involved in abietic acid biosynthesis

Arch. Biochem. Biophys.

308

258-266

1994

Abies grandis, Pinus contorta

8311462

694704

Funk, C.; Lewinsohn, E.; Vogel, B.; Steele, C.; Croteau, R.

Regulation of oleoresinosis in grand fir (Abies grandis). Coordinate induction of monoterpene and diterpene cyclases and two cytochrome P450-dependent diterpenoid hydroxylases by stem wounding

Plant Physiol.

106

999-1005

1994

Abies grandis

12232380