EC Number   |
General Information |
Reference |
|---|
   2.3.1.B44 | physiological function |
ectopic expression of NAA80 in a yeast strain lacking NatB activity partially restores N-terminal acetylation of NatB substrates, including yeast actin |
758238 |
| 2.3.1.B44 | physiological function |
enzyme N-acetylates actin. Actin N-terminal acetylation plays crucial roles in cytoskeletal assembly in vitro and in cells. The absence of N-terminal acetylation leads to significant differences in the rates of actin filament depolymerization and elongation, including elongation driven by formins, whereas filament nucleation by the Arp2/3 complex is mostly unaffected. NAA80-knockout cells display severely altered cytoskeletal organization, including an increase in the ratio of filamentous to globular actin, increased filopodia and lamellipodia formation, and accelerated cell motility |
758237 |
| 2.3.1.B44 | physiological function |
NAT6 acetylates the N-termini of acidic peptides corresponding to actin N-termini. Peptides corresponding to the N-terminus of different forms of actin are excellent substrates for NAT6. NAT6 is not required for the acetylation of the initiator methionine of gamma-actin 1 or beta-actin, and loss of NAT6 does not affect F-filament network |
756706 |
