Literature summary for 2.3.1.B44 extracted from

Drazic, A.; Aksnes, H.; Marie, M.; Boczkowska, M.; Varland, S.; Timmerman, E.; Foyn, H.; Glomnes, N.; Rebowski, G.; Impens, F.; Gevaert, K.; Dominguez, R.; Anesen, T.
NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility (2018), Proc. Natl. Acad. Sci. USA, 115, 4399-4404 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in HAP1-cell	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	diffuse cytosolic distribution	Homo sapiens	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q93015	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + actin	-	Homo sapiens	CoA + N-acetyl-actin	-	?
additional information	substrates are peptides corresponding to the fully processed N termini of beta- and gamma-actin	Homo sapiens	?	-	-

Synonyms

Synonyms	Comment	Organism
NAA80	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	enzyme N-acetylates actin. Actin N-terminal acetylation plays crucial roles in cytoskeletal assembly in vitro and in cells. The absence of N-terminal acetylation leads to significant differences in the rates of actin filament depolymerization and elongation, including elongation driven by formins, whereas filament nucleation by the Arp2/3 complex is mostly unaffected. NAA80-knockout cells display severely altered cytoskeletal organization, including an increase in the ratio of filamentous to globular actin, increased filopodia and lamellipodia formation, and accelerated cell motility	Homo sapiens

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Release 2023.1 (January 2023)