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Literature summary for 2.3.1.B44 extracted from

  • Wiame, E.; Tahay, G.; Tyteca, D.; Vertommen, D.; Stroobant, V.; Bommer, G.T.; Van Schaftingen, E.
    NAT6 acetylates the N-terminus of different forms of actin (2018), FEBS J., 285, 3299-3316 .
    View publication on PubMed
Search for more literature for 2.3.1.B44

Cloned(Commentary)

Cloned (Comment) Organism
expression in HAP-1 cell Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.4
-
 DDDIAA pH 7.5, 30°C Homo sapiens
0.5
-
 MDDDIAA pH 7.5, 30°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q93015
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphoblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + CDEDETT peptide dervied from alpha-actin 1 N-terminus Homo sapiens CoA + N-acetyl-CDEDETT
-
 ?
acetyl-CoA + CEEEDST best substrate Homo sapiens CoA + N-acetyl-CEEEDST
-
 ?
acetyl-CoA + DDDIAA peptide dervied from beta-actin N-terminus Homo sapiens CoA + N-acetyl-DDDIAA
-
 ?
acetyl-CoA + MCDEDET peptide dervied from alpha-actin 1 N-terminus Homo sapiens CoA + N-acetyl-MCDEDET
-
 ?
acetyl-CoA + MCEEEDS
-
 Homo sapiens CoA + N-acetyl-MCEEEDS
-
 ?
acetyl-CoA + MDDDIAA peptide dervied from beta-actin N-terminus Homo sapiens CoA + N-acetyl-MDDDIAA
-
 ?
acetyl-CoA + MEEEIAA peptide dervied from gamma-actin 1 N-terminus Homo sapiens CoA + N-acetyl-MEEEIAA
-
 ?

Synonyms

Synonyms Comment Organism
Fus2
-
 Homo sapiens
N-alpha-acetyltransferase 80
-
 Homo sapiens
NAA80
-
 Homo sapiens
NAT6
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function NAT6 acetylates the N-termini of acidic peptides corresponding to actin N-termini. Peptides corresponding to the N-terminus of different forms of actin are excellent substrates for NAT6. NAT6 is not required for the acetylation of the initiator methionine of gamma-actin 1 or beta-actin, and loss of NAT6 does not affect F-filament network Homo sapiens