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2.3.1.286: protein acetyllysine N-acetyltransferase

This is an abbreviated version!
For detailed information about protein acetyllysine N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.286

Reaction

[protein]-N6-acetyl-L-lysine
+
NAD+
 +
H2O
=
[protein]-L-lysine
 +
2''-O-acetyl-ADP-D-ribose
 +
nicotinamide

Synonyms

Af2Sir2, Clr3, CobB, HDAC, histone deacetylase, Hst1, HST2, Hst2p, KAT, More, NAD+-dependent protein deacetylase, NAD-dependent histone deacetylase, NAD-dependent protein deacetylase, nicotinamide adenine dinucleotide-dependent protein deacetylase, patZ, peptidyl-lysine N-acetyltransferase, phnO, protein lysine acetyltransferase, protein lysine deacetylase, Rv1151c, silent information regulator 2, Sir-2, Sir2, SIR2-Af1, Sir2-Af2, Sir2A, Sir2Af2, Sir2alpha, Sir2p, SIRT1, SIRT2, SIRT3, SIRT5, sirtuin, sirtuin 1, sirtuin 3, sirtuin-2 deacetylase, YfiQ, YiaC, YjaB

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.286 protein acetyllysine N-acetyltransferase

Expression

Expression on EC 2.3.1.286 - protein acetyllysine N-acetyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
down-regulation of intratumoral and peritumoral Sirt3 are both associated with poor outcome in hepatocellular carcinoma
enhanced expression of SIRT5 in the cerebral tissue of calorie restriction rats compared with rats that remained fed ad libitum
-
expression of SIRT1 is induced in human cells that are treated with human serum. Insulin and insulin-like growth factor 1 (IGF-1) attenuate this response
Q96EB6
expression of SIRT1 is induced in rat cells that are treated with rat serum. Insulin and insulin-like growth factor 1 (IGF-1) attenuate this response
Q96EB6
expression of SIRT3 shows a strong negative correlation with the progression of Alzheimer’s disease
grape seed proanthocyanidin consumption robustly enhances both the hepatic Sirt1 mRNA levels and SIRT1 activity in a dose-dependent manner
-
ischemia-reperfusion induces a transient upregulation of isoform SIRT1
-
isoform SIRT1 activity is down-regulated in the brains of two complementary Huntington's disease mouse models
Q923E4
isoform SIRT1 mRNA is upregulated in chronic lymphocytic leukemia
-
isoform SIRT3 expression is reduced in human pancreatic tumors
tissues are extracted from 12-month-old rats that had either been fed ad libitum (AL) or a caloric restriction diet (CR, 60% of AL) since weaning. Compared to expression in AL animals, SIRT1 expression is higher in many tissues of the CR animals, including brain, visceral fat pads, kidney, and liver
Q96EB6