Activating Compound | Comment | Organism | Structure |
---|---|---|---|
resveratrol | resveratrol restores SIRT1 activity and NAD+ level by an AMPK-dependent mechanism | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sirtinol | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [Fluor de Lys protein]-N6-acyl-L-lysine | Rattus norvegicus | - |
nicotinamide + [Fluor de Lys protein]-L-lysine + 2'-O-acyl-ADP-ribose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiomyocyte | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [Fluor de Lys protein]-N6-acyl-L-lysine | - |
Rattus norvegicus | nicotinamide + [Fluor de Lys protein]-L-lysine + 2'-O-acyl-ADP-ribose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SIRT1 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | dependent on | Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | ischemia-reperfusion induces a transient upregulation of isoform SIRT1 | up |
General Information | Comment | Organism |
---|---|---|
malfunction | NAD+-dependent SIRT1 deactivation has a key role on ischemia-reperfusion-induced apoptosis | Rattus norvegicus |