1.21.4.5: tetrachlorohydroquinone reductive dehalogenase

This is an abbreviated version!
For detailed information about tetrachlorohydroquinone reductive dehalogenase, go to the full flat file.

Word Map on EC 1.21.4.5

1.21.4.5

pentachlorophenol

dehalogenation

trichlorohydroquinone

chlorophenolicum

s-transferase

sphingobium

dithiothreitol

chlorinate

sphingomonas

gst

maleylacetoacetate

thiol-disulfide

glutathione-dependent

isomerization

deprotonated

maleylacetone

maleylpyruvate

electrophilic

cosubstrate

elementary

pcp

chrysosporium

aldolase

theta

phanerochaete

Reaction

+ 2 glutathione

Synonyms

PCP hydroxylase, pcpC, TCHQ dehalogenase, tetrachloro-p-hydroquinone reductive dehalogenase, tetrachlorohydroquinone dehalogenase, tetrachlorohydroquinone reductive dehalogenase

ECTree

1 Oxidoreductases

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.4 With a disulfide as acceptor

1.21.4.5 tetrachlorohydroquinone reductive dehalogenase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
1	Activating Compound
2	AA Sequence
3	Cloned(Commentary)
3	General Information
4	Inhibitors
4	kcat/KM [mM/s]
1	Ki Value [mM]
10	KM Value [mM]
1	Metals/Ions
5	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
10	Organism
2	Oxidation Stability
3	Pathway
3	pH Optimum
1	pH Range
1	pI Value
10	Protein Variants
6	Purification (Commentary)
2	Reaction
10	Reference
1	Specific Activity [micromol/min/mg]
2	Storage Stability
36	Substrates and Products (Substrate)
4	Subunits
17	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

Systematic Name

print visible entries

print all entries

Systematic Name on EC 1.21.4.5 - tetrachlorohydroquinone reductive dehalogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Systematic Name Search

glutathione disulfide:2,6-dichlorohydroquinone (chlorinating)

The enzyme, characterized from the bacterium Sphingobium chlorophenolicum, converts tetrachlorohydroquinone to 2,6-dichlorohydroquinone in two steps, via 2,3,6-trichlorohydroquinone, using glutathione as the reducing agent. The enzyme is sensitive to oxidation - when an internal L-cysteine residue is oxidized, the enzyme produces 2,3,5-trichloro-6-(glutathion-S-yl)-hydroquinone and 2,6-dichloro-3-(glutathion-S-yl)-hydroquinone instead of its normal products.