1.21.4.5: tetrachlorohydroquinone reductive dehalogenase
This is an abbreviated version!
For detailed information about tetrachlorohydroquinone reductive dehalogenase, go to the full flat file.
Word Map on EC 1.21.4.5
-
1.21.4.5
-
pentachlorophenol
-
dehalogenation
-
trichlorohydroquinone
-
chlorophenolicum
-
s-transferase
-
sphingobium
-
dithiothreitol
-
chlorinate
-
sphingomonas
-
gst
-
maleylacetoacetate
-
thiol-disulfide
-
glutathione-dependent
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isomerization
-
deprotonated
-
maleylacetone
-
maleylpyruvate
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electrophilic
-
cosubstrate
-
elementary
-
pcp
-
chrysosporium
-
aldolase
-
theta
-
phanerochaete
- 1.21.4.5
- pentachlorophenol
-
dehalogenation
-
trichlorohydroquinone
- chlorophenolicum
- s-transferase
-
sphingobium
- dithiothreitol
-
chlorinate
- sphingomonas
- gst
- maleylacetoacetate
-
thiol-disulfide
-
glutathione-dependent
-
isomerization
-
deprotonated
- maleylacetone
- maleylpyruvate
-
electrophilic
-
cosubstrate
-
elementary
- pcp
-
chrysosporium
- aldolase
- theta
-
phanerochaete
Reaction
Synonyms
PCP hydroxylase, pcpC, TCHQ dehalogenase, tetrachloro-p-hydroquinone reductive dehalogenase, tetrachlorohydroquinone dehalogenase, tetrachlorohydroquinone reductive dehalogenase
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Inhibitors
Inhibitors on EC 1.21.4.5 - tetrachlorohydroquinone reductive dehalogenase
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2,3,6-trichlorohydroquinone
noncompetitive inhibitor of the thiol-disulfide exchange reaction, in addition, dissociation of the GSSG product is inhibited by 2,3,6-trichlorohydroquinone
additional information
PcpC is not inhibited by the 2,3,5,6-tetrachlorohydroquinone substrate at concentrations 0.3 mM
-
inhibits the wild-typ enzyme and not the mutant enzyme
2,3,5,6-tetrachlorohydroquinone
mutant enzymes S15A and S12A displayed substrate inhibition above 0.035 mM