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1.14.20.B3: cycloclavine dioxygenase (alternatively: multifunctional dioxygenase EasH)

This is an abbreviated version!
For detailed information about cycloclavine dioxygenase (alternatively: multifunctional dioxygenase EasH), go to the full flat file.

Reaction

an ergot alkaloid
+
O2
+
2-oxoglutarate
=
a cyclopropyl-ergot alkaloid
+
succinate
+
CO2
+
H2O

Synonyms

EasH

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated
                1.14.20.B3 cycloclavine dioxygenase (alternatively: multifunctional dioxygenase EasH)

Reference

Reference on EC 1.14.20.B3 - cycloclavine dioxygenase (alternatively: multifunctional dioxygenase EasH)

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jakubczyk, D.; Caputi, L.; Hatsch, A.; Nielsen, C.A.F.; Diefenbacher, M.; Klein, J.; Molt, A.; Schröder, H.; Cheng, J.Z.; Naesby, M.; O'Connor, S.E.
Discovery and reconstitution of the cycloclavine biosynthetic pathway - enzymatic formation of a cyclopropyl group
Angew. Chem. Int. Ed. Engl.
54
5117-5121
2015
Aspergillus japonicus (A0A1L1QK38)
Manually annotated by BRENDA team
Jakubczyk, D.; Caputi, L.; Stevenson, C.E.M.; Lawson, D.M.; O'Connor, S.E.
Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis
Chem. Commun. (Camb.)
52
14306
2016
Aspergillus japonicus (A0A1L1QK38)
Manually annotated by BRENDA team
Jakubczyk, D.; Caputi, L.; Stevenson, C.E.M.; Lawson, D.M.; O'Connor, S.E.
Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis
Chem. Commun. (Camb.)
52
14306-14309
2016
Aspergillus japonicus (A0A1L1QK38)
Manually annotated by BRENDA team