2.4.1.142: chitobiosyldiphosphodolichol beta-mannosyltransferase
This is an abbreviated version!
For detailed information about chitobiosyldiphosphodolichol beta-mannosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.142
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2.4.1.142
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oligosaccharide
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n-glycosylation
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mannosylation
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dolichol-linked
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lipid-linked
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n-linked
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n-glycans
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asparagine-linked
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disease-causing
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glycosylphosphatidylinositol
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glycolipids
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rough
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pharmacology
- 2.4.1.142
- oligosaccharide
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n-glycosylation
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mannosylation
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dolichol-linked
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lipid-linked
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n-linked
- n-glycans
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asparagine-linked
-
disease-causing
- glycosylphosphatidylinositol
- glycolipids
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rough
- pharmacology
Reaction
Synonyms
ALG1, ALG1 beta1,4 mannosyltransferase, Alg1 mannosyltransferase, Alg1 protein, Alg1p, beta-1,4 mannosyltransferase, beta1,4-MT, chitobiosyldiphosphodolichol beta-mannosyltransferase, GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase, GDP-mannose-dolichol diphosphochitobiose mannosyltransferase, guanosine diphosphate-mannose:GlcNAc2-PP-dolichol mannosyltransferase-1, guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase, mannosyltransferase I, MT-1, MT-I
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General Information on EC 2.4.1.142 - chitobiosyldiphosphodolichol beta-mannosyltransferase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
malfunction
a deficiency in guanosine diphosphate-mannose:GlcNAc2-PP-dolichol mannosyltransferase-1 causes type I congenital disorders of glycosylation
metabolism
for proper accomplishment of protein N-glycosylation, early assembly of dolichol-linked oligosaccharides on cytoplasmic side of the rough endoplasmic reticulum membrane must progress at a rate greater than subsequent flipping of dolichol-linked oligosaccharides into luminal side. To assure this, all activities of five glycosyltransferases involved in early DLO assembly are required in addition to their substrates. If any of them is diminished, eukaryotic cell would not be able to survive
physiological function
additional information
physiological function
the enzyme is involved in the early assembly of dolichol-linked oligosaccharides. Early dolichol-linked oligosaccharide assembly from dolichyl phosphate to Man5GlcNAc2-PP-Dol is a fundamental and essential event for viability of eukaryotic cells, especially multicellular organisms. Analysis of transcriptional regulation, overview. The 200 bp region upstream from HMT-1 open reading frame is crucial for both positive and negative regulation of the HMT-1 transcription
physiological function
ALG1 is presumed to be involved in the regulation of the protein N-glycosylation. Genetic association of WDR3 and ALG1 in schizophrenia
physiological function
ALG1 is presumed to be involved in the regulation of the protein N-glycosylation. Genetic association of WDR3 and ALG1 in schizophrenia. The WDR3 gene may likely be a sensitive factor in female patients with schizophrenia
additional information
Alg1, a beta-1,4 mannosyltransferase (MTase), physically interacts with Alg2 (EC 2.4.1.132) and Alg11 (EC 2.4.1.257) proteins to form the multienzyme complex which catalyzes the addition of all five mannose to generate the Man5GlcNAc2-PP-Dol intermediate. Alg1 plays a central role in the formation of the multi-MTase, the topological information of Alg1 including the molecular mechanism of membrane association is analyzed. Alg1 shares structure similarity with Alg13/14 complex, which has been defined as a membrane-associated GT-B GTase, structural similarities, overview
additional information
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Alg1, a beta-1,4 mannosyltransferase (MTase), physically interacts with Alg2 (EC 2.4.1.132) and Alg11 (EC 2.4.1.257) proteins to form the multienzyme complex which catalyzes the addition of all five mannose to generate the Man5GlcNAc2-PP-Dol intermediate. Alg1 plays a central role in the formation of the multi-MTase, the topological information of Alg1 including the molecular mechanism of membrane association is analyzed. Alg1 shares structure similarity with Alg13/14 complex, which has been defined as a membrane-associated GT-B GTase, structural similarities, overview
additional information
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Alg1, a beta-1,4 mannosyltransferase (MTase), physically interacts with Alg2 (EC 2.4.1.132) and Alg11 (EC 2.4.1.257) proteins to form the multienzyme complex which catalyzes the addition of all five mannose to generate the Man5GlcNAc2-PP-Dol intermediate. Alg1 plays a central role in the formation of the multi-MTase, the topological information of Alg1 including the molecular mechanism of membrane association is analyzed. Alg1 shares structure similarity with Alg13/14 complex, which has been defined as a membrane-associated GT-B GTase, structural similarities, overview
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