2.3.1.295: mycoketide-CoA synthase

This is an abbreviated version!
For detailed information about mycoketide-CoA synthase, go to the full flat file.

Word Map on EC 2.3.1.295

2.3.1.295

tuberculosis

fusarium

graminearum

aurofusarin

avium

phthiocerol

blight

gibberella

mannosyl

anamorph

pathogen-associated

laccase

acylase

pseudograminearum

Reaction

+ 5 malonyl-CoA + 5 (S)-methylmalonyl-CoA + 22 NADPH + 22 H+ =

+ 10 CO2 + 10 CoA + 22 NADP⁺ + 11 H2O

Synonyms

pks12, polyketide synthase 12

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.295 mycoketide-CoA synthase

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Results	in table
1	AA Sequence
2	Cloned(Commentary)
2	General Information
2	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
384	Organism
1	Pathway
4	Protein Variants
1	Purification (Commentary)
1	Reaction
4	Reference
17	Substrates and Products (Substrate)
2	Subunits
7	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.3.1.295 - mycoketide-CoA synthase

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malonyl-CoA/(S)-methylmalonyl-CoA:heptanoyl-CoA malonyltransferase (mycoketide-CoA-forming)

The enzyme, found in mycobacteria, is involved in the synthesis of beta-D-mannosyl phosphomycoketides. It is a very large polyketide synthase that contains two complete sets of FAS-like fatty acid synthase modules. It binds an acyl-CoA with 5-9 carbons as a starter unit, and extends it by five rounds of alternative additions of malonyl-CoA and methylmalonyl-CoA extender units. Depending on the starter unit, the enzyme forms mycoketide-CoAs of different lengths.