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2.3.1.295: mycoketide-CoA synthase

This is an abbreviated version!
For detailed information about mycoketide-CoA synthase, go to the full flat file.

Word Map on EC 2.3.1.295

Reaction

a medium-chain acyl-CoA
+ 5 malonyl-CoA + 5 (S)-methylmalonyl-CoA + 22 NADPH + 22 H+ =
a mycoketide-CoA
+ 10 CO2 + 10 CoA + 22 NADP+ + 11 H2O

Synonyms

pks12, polyketide synthase 12

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.295 mycoketide-CoA synthase

Reference

Reference on EC 2.3.1.295 - mycoketide-CoA synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Matsunaga, I.; Bhatt, A.; Young, D.C.; Cheng, T.Y.; Eyles, S.J.; Besra, G.S.; Briken, V.; Porcelli, S.A.; Costello, C.E.; Jacobs, W.R.; Moody, D.B.
Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells
J. Exp. Med.
200
1559-1569
2004
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team
Chopra, T.; Banerjee, S.; Gupta, S.; Yadav, G.; Anand, S.; Surolia, A.; Roy, R.P.; Mohanty, D.; Gokhale, R.S.
Novel intermolecular iterative mechanism for biosynthesis of mycoketide catalyzed by a bimodular polyketide synthase
PLoS Biol.
6
e163
2008
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team