2.3.1.289: aureothin polyketide synthase system
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For detailed information about aureothin polyketide synthase system, go to the full flat file.
Reaction
Synonyms
aurABC, aureothin polyketide synthase complex
ECTree
2.3.1.289 aureothin polyketide synthase systemAdvanced search results
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| 1 | Cloned(Commentary) |
| 8 | General Information |
| 30 | Organism |
| 4 | Protein Variants |
| 1 | Reaction |
| 10 | Reference |
| 4 | Substrates and Products (Substrate) |
| 2 | Synonyms |
| 1 | Systematic Name |
Systematic Name
Systematic Name on EC 2.3.1.289 - aureothin polyketide synthase system
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SYSTEMATIC NAME 
IUBMB Comments
malonyl-CoA/(S)-methylmalonyl-CoA:4-nitrobenzoyl-CoA (methyl)malonyltransferase (demethylluteothin-forming)
This polyketide synthase, characterized from the bacterium Streptomyces thioluteus, generates the backbone of the antibiotic aureothin. It is composed of 4 modules that total 18 domains and is encoded by three genes. The enzyme accepts the unusual starter unit 4-nitrobenzoyl-CoA and extends it by 4 molecules of (S)-methylmalonyl-CoA and a single molecule of malonyl-CoA. The first module (encoded by aurA) is used twice in an iterative fashion, so that the five Claisen condensation reactions are catalysed by only four modules. The iteration becomes possible by the transfer of the [acp]-bound polyketide intermediate back to the ketosynthase (KS) domain on the opposite polyketide synthase strand (polyketides are homodimeric).
