2.3.1.289: aureothin polyketide synthase system

This is an abbreviated version!
For detailed information about aureothin polyketide synthase system, go to the full flat file.

Reaction

+ 4 (S)-methylmalonyl-CoA + 4 NADPH + 4 H+ =

+ 5 CO2 + 6 CoA + 4 NADP⁺ + 3 H2O

Synonyms

aurABC, aureothin polyketide synthase complex

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.289 aureothin polyketide synthase system

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Results	in table
1	Cloned(Commentary)
8	General Information
30	Organism
4	Protein Variants
1	Reaction
10	Reference
4	Substrates and Products (Substrate)
2	Synonyms
1	Systematic Name

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Reference on EC 2.3.1.289 - aureothin polyketide synthase system

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752486

Sugimoto, Y.; Ding, L.; Ishida, K.; Hertweck, C.

Rational design of modular polyketide synthases morphing the aureothin pathway into a luteoreticulin assembly line

Angew. Chem. Int. Ed. Engl.

1560-1564

2014

Streptomyces thioluteus (Q70KH8 and Q70KH5 and Q70KH4), Streptomyces thioluteus HKI-227 (Q70KH8 and Q70KH5 and Q70KH4)

24402879

753232

He, J.; Hertweck, C.

Iteration as programmed event during polyketide assembly; molecular analysis of the aureothin biosynthesis gene cluster

Chem. Biol.

1225-1232

2003

Streptomyces thioluteus (Q70KH8 and Q70KH5 and Q70KH4), Streptomyces thioluteus HKI-227 (Q70KH8 and Q70KH5 and Q70KH4)

753269

He, J.; Hertweck, C.

Functional analysis of the aureothin iterative type I polyketide syntase

ChemBioChem

908-912

2005

Streptomyces thioluteus (Q70KH8 and Q70KH5 and Q70KH4), Streptomyces thioluteus HKI-227 (Q70KH8 and Q70KH5 and Q70KH4)

15812854

753270

Traitcheva, N.; Jenke-Kodama, H.; He, J.; Dittmann, E.; Hertweck, C.

Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways An evolutionary perspective

ChemBioChem

1841-1849

2007

Streptomyces thioluteus (Q70KH8 and Q70KH5 and Q70KH4), Streptomyces thioluteus HKI-227 (Q70KH8 and Q70KH5 and Q70KH4)

17763486

755024

Busch, B.; Hertweck, C.

Evolution of metabolic diversity in polyketide-derived pyrones Using the non-colinear aureothin assembly line as a model system

Phytochemistry

1833-1840

2009

Streptomyces thioluteus (Q70KH8 and Q70KH5 and Q70KH4), Streptomyces thioluteus HKI-227 (Q70KH8 and Q70KH5 and Q70KH4)

19651421