2.3.1.265: phosphatidylinositol dimannoside acyltransferase

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For detailed information about phosphatidylinositol dimannoside acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.265

2.3.1.265

mannosides

mycobacterial

6-position

glycolipids

phosphatidyl-myo-inositol

phospholipid

palmitoyl

mannose

lipomannan

host-pathogen

lipoarabinomannan

envelope

smegmatis

palmitoyl-coa

mannosyltransferases

palmitate

transacylase

lipoglycans

fluidity

Reaction

2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol

2-O-(6-O-acyl-alpha-D-mannosyl)-6-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol

Synonyms

acyltransferase PatA, membrane acyltransferase, MSMEG 2934 protein, MSMEG_2934, PatA, phosphatidylinositol mannoside acyltransferase, PIM acyltransferase, PIM2 acyltransferase, ptfP1, Rv2611c

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.265 phosphatidylinositol dimannoside acyltransferase

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Results	in table
6	AA Sequence
3	Cloned(Commentary)
2	Crystallization (Commentary)
36	General Information
1	Inhibitors
37	Localization
24	Natural Substrates/ Products (Substrates)
32	Organism
3	Pathway
4	PDB ID
24	Protein Variants
3	Purification (Commentary)
2	Reaction
18	Reference
45	Substrates and Products (Substrate)
8	Subunits
57	Synonyms
1	Systematic Name

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Reference on EC 2.3.1.265 - phosphatidylinositol dimannoside acyltransferase

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742827

Kordulakova, J.; Gilleron, M.; Puzo, G.; Brennan, P.J.; Gicquel, B.; Mikusova, K.; Jackson, M.

Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of Mycobacterium species

J. Biol. Chem.

278

36285-36295

2003

Mycobacterium tuberculosis (P9WMB5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WMB5)

12851411

743339

Albesa-Jove, D.; Svetlikova, Z.; Tersa, M.; Sancho-Vaello, E.; Carreras-Gonzalez, A.; Bonnet, P.; Arrasate, P.; Eguskiza, A.; Angala, S.K.; Cifuente, J.O.; Kordulakova, J.; Jackson, M.; Mikusova, K.; Guerin, M.E.

Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA

Nat. Commun.

10906

2016

Mycolicibacterium smegmatis (A0QWG5), Mycolicibacterium smegmatis, Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 (A0QWG5)

26965057

743729

Svetlikova, Z.; Barath, P.; Jackson, M.; Kordulakova, J.; Mikusova, K.

Purification and characterization of the acyltransferase involved in biosynthesis of the major mycobacterial cell envelope glycolipid-monoacylated phosphatidylinositol dimannoside

Protein Expr. Purif.

100

33-39

2014

Mycolicibacterium smegmatis (A0QWG5), Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 (A0QWG5)

24810911

755684

Tersa, M.; Raich, L.; Albesa-Jove, D.; Trastoy, B.; Prandi, J.; Gilleron, M.; Rovira, C.; Guerin, M.E.

The molecular mechanism of substrate recognition and catalysis of the membrane acyltransferase PatA from Mycobacteria

ACS Chem. Biol.

131-140

2018

Mycolicibacterium smegmatis (A0QWG5), Mycobacterium tuberculosis (P9WMB5), Mycobacterium tuberculosis, Mycolicibacterium smegmatis ATCC 700084 (A0QWG5), Mycobacterium tuberculosis H37Rv (P9WMB5), Mycobacterium tuberculosis ATCC 25618 (P9WMB5), Mycolicibacterium smegmatis mc(2)155 (A0QWG5)

29185694

756084

Sancho-Vaello, E.; Albesa-Jove, D.; Rodrigo-Unzueta, A.; Guerin, M.

Structural basis of phosphatidyl-myo-inositol mannosides biosynthesis in mycobacteria

Biochim. Biophys. Acta

1862

1355-1367

2017

Mycolicibacterium smegmatis (A0QWG5), Mycobacterium tuberculosis (P9WMB5), Mycolicibacterium smegmatis ATCC 700084 (A0QWG5), Mycobacterium tuberculosis H37Rv (P9WMB5), Mycobacterium tuberculosis ATCC 25618 (P9WMB5), Mycolicibacterium smegmatis mc(2)155 (A0QWG5)

27826050