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2.3.1.265: phosphatidylinositol dimannoside acyltransferase

This is an abbreviated version!
For detailed information about phosphatidylinositol dimannoside acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.265

Reaction

an acyl-CoA
+
2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol
=
CoA
 +
2-O-(6-O-acyl-alpha-D-mannosyl)-6-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol

Synonyms

acyltransferase PatA, membrane acyltransferase, MSMEG 2934 protein, MSMEG_2934, PatA, phosphatidylinositol mannoside acyltransferase, PIM acyltransferase, PIM2 acyltransferase, ptfP1, Rv2611c

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.265 phosphatidylinositol dimannoside acyltransferase

Crystallization

Crystallization on EC 2.3.1.265 - phosphatidylinositol dimannoside acyltransferase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
purified recombinant enzyme, cyrstallization attempts in the presence of Ac1PIM1/Ac2PIM1, Ac1PIM2/Ac2PIM2, or their deacylated analogues are unsuccessful. Crystallization of the enzyme in the presence of mannose phosphate, X-ray diffraction structure detremination and analysis at 2.42 A resolution, molecular replacement method and modelling
using 100mM Tris-HCl pH 7.0, 230 mM MgCl2 and 12-16% (w/v) PEG 8000