2.3.1.263: 2-amino-4-oxopentanoate thiolase
This is an abbreviated version!
For detailed information about 2-amino-4-oxopentanoate thiolase, go to the full flat file.
Reaction
Synonyms
2-amino-4-ketopentanoate thiolase, AKP thiolase, AKP-thiolase, AKPT
ECTree
2.3.1.263 2-amino-4-oxopentanoate thiolaseAdvanced search results
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Substrates Products on EC 2.3.1.263 - 2-amino-4-oxopentanoate thiolase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CoA + 2-amino-4-oxopentanoate + CoA
acetyl-CoA + D-alanine
-
catalyzes a step in the ornithine fermentation pathway
-
-
?
CoA + 2-amino-4-ketopentanoate
acetyl-CoA + D-alanine
-
catalyzes a step in the ornithine fermentation pathway
-
-
r
CoA + 2-amino-4-ketopentanoate
acetyl-CoA + D-alanine
-
catalyzes a step in the ornithine fermentation pathway
-
-
r
CoA + 2-amino-4-oxopentanoate
acetyl-CoA + D-alanine
catalyzes a step in the ornithine fermentation pathway
-
-
r
CoA + 2-amino-4-oxopentanoate
acetyl-CoA + D-alanine
strict substrate specificity. No activity with other proteogenic amino acid nor with propional-CoA, crotonyl-CoA, succinyl-CoA, butyryl-CoA or malonyl-CoA. In the reverse reaction formation of CoA-SH is observed only in the presence of D-alanine as substrate and not in that of the L-isomer
-
-
r
