2.3.1.1: amino-acid N-acetyltransferase

This is an abbreviated version!
For detailed information about amino-acid N-acetyltransferase, go to the full flat file.

Reaction

Synonyms

acetylglutamate synthase, acetylglutamate synthetase, acetylglutamic synthetase, acetyltransferase, amino acid, AGAS, amino acid acetyltransferase, ARG2, ArgA, ArgH(A), argJ, Cg3035, More, N-acetyl-glutamate synthase, N-acetyl-L-glutamate synthase, N-acetyl-L-glutamate synthase/kinase, N-acetyl-L-glutamate synthetase, N-acetylglutamate synthase, N-acetylglutamate synthase/kinase, N-acetylglutamate synthetase, NAGS, NAGS-K, NAGS/K, NAT, ngNAGS, PaNAGS, pitax, Rv2747, SINAGS1, XcNAGS

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.1 amino-acid N-acetyltransferase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
26	Activating Compound
39306	AA Sequence
5	Application
1	CAS Registry Number
41	Cloned(Commentary)
7	Cofactor
13	Crystallization (Commentary)
244	Disease/ Diagnostics
6	Expression
8	General Information
9	General Stability
9	IC50 Value
108	Inhibitors
18	Ki Value [mM]
89	KM Value [mM]
8	Localization
33	Molecular Weight [Da]
37	Natural Substrates/ Products (Substrates)
103	Organism
8	Pathway
50	PDB ID
21	pH Optimum
2	pH Range
2	pH Stability
2	Posttranslational Modification
82	Protein Variants
37	Purification (Commentary)
3	Reaction
1	Reaction Type
88	Reference
42	Source Tissue
85	Specific Activity [micromol/min/mg]
3	Storage Stability
117	Substrates and Products (Substrate)
30	Subunits
119	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
4	Temperature Range [°C]
10	Temperature Stability [°C]
2	Turnover Number [1/s]

General Information

print visible entries

print all entries

General Information on EC 2.3.1.1 - amino-acid N-acetyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to General Information Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Homo sapiens

Q8N159

enzyme deficiency results in elevated levels of plasma ammonia which is neurotoxic

737116

metabolism

2 entries

physiological function

5 entries

metabolism

Saccharolobus solfataricus

-

Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized

725629

metabolism

Saccharolobus solfataricus P1

-

Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized

-

physiological function

Pseudomonas aeruginosa

-

first enzyme of bacterial and plant arginine biosynthesis, activator of urea cycle in animals

703712

physiological function

Pseudomonas aeruginosa

P22567

first enzyme of bacterial and plant arginine biosynthesis, activator of urea cycle in animals

703696

physiological function

Neisseria gonorrhoeae

Q5FAK7

first step in L-arginine biosynthesis in plants and micro organsims, inactive T-state with L-arginine bound and active R-state complexed with CoA and L-glutamate

704614

physiological function

Homo sapiens

Q8N159

N-acetylglutamate synthase catalyzes the synthesis of N-acetyl-L-glutamate, an obligate cofactor for carbamyl phosphate synthetase I in the urea cycle. An N-terminal proline-rich motif of the enzyme is likely to function in signal transduction to carbamyl phosphate synthetase I, CPS1

737116

physiological function

Danio rerio

-

the enzyme plays a role in citrulline and/or arginine biosynthesis during the first day of development and in ammonia detoxification thereafter

737139