2.1.1.B123: 16S rRNA (uridine1369-2'-O)-methyltransferase
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For detailed information about 16S rRNA (uridine1369-2'-O)-methyltransferase, go to the full flat file.
Reaction
Synonyms
FtsJ2, MRM2, RRMJ2
ECTree
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General Information
General Information on EC 2.1.1.B123 - 16S rRNA (uridine1369-2'-O)-methyltransferase
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physiological function
MRM2 and MRM3 are responsible for modification of nucleotides of the 16S rRNA A-loop, an essential component of the peptidyl transxadferase center. Inactivation of MRM2 or MRM3 in human cells by RNA interference results in respiratory incompetence as a consequence of diminished mitochondrial translation. Ineffective translation in MRM2- and MRM3-depleted cells results from aberxadrant assembly of the large subunit of the mitochondrial ribosome
physiological function
siRNA directed against MRM2 results in loss of methylation at at residue U1369 of 16S RNA and in a general suppression of cell growth