2.1.1.B123: 16S rRNA (uridine1369-2'-O)-methyltransferase

This is an abbreviated version!
For detailed information about 16S rRNA (uridine1369-2'-O)-methyltransferase, go to the full flat file.

Reaction

Synonyms

FtsJ2, MRM2, RRMJ2

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.B123 16S rRNA (uridine1369-2'-O)-methyltransferase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
1	AA Sequence
1	Application
2	Cloned(Commentary)
2	General Information
1	Localization
2	Natural Substrates/ Products (Substrates)
3	Organism
1	Protein Variants
1	Reaction
3	Reference
2	Source Tissue
2	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name

Application

print visible entries

print all entries

Application on EC 2.1.1.B123 - 16S rRNA (uridine1369-2'-O)-methyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Application Search

medicine

Homo sapiens

Q9UI43

mutation G189R identified in a 7-year-old boy with childhood-onset rapidly progressive encephalomyopathy and stroke-like episodes. Multiple OXPHOS defects and decreased mtDNA copy number (40%) are detected in muscle homogenate. Symptoms are similar to mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome. A yeast MRM2 knockout mutant shows a defect in respiration and the reduction of the 2'-O-methylmodification at position U2791 in the yeast mitochondrial 21S rRNA. Complementation of the yeast knockout mutant with the human mutant Mrm2 fails to rescue the respiratory phenotype, which is instead completely rescued by expressing the wild-type allele

756899