Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.1.1.356: [histone H3]-lysine27 N-trimethyltransferase

This is an abbreviated version!
For detailed information about [histone H3]-lysine27 N-trimethyltransferase, go to the full flat file.

Word Map on EC 2.1.1.356

Reaction

3 S-adenosyl-L-methionine +

a [histone H3]-L-lysine27
= 3 S-adenosyl-L-homocysteine +
a [histone H3]-N6,N6,N6-trimethyl-L-lysine27

Synonyms

CLF, EC 2.1.1.43, EZH1, EZH2, G9a, histone H3 K27 methyltransferase, histone H3 lysine 27 methyltransferase, histone lysine methyltransferase, HMTase, interleukin-5 response element II binding protein, KMT6, KMT6A, KMT6B, lysine-preferring HMTase, NSD2, NSD3, Polycomb repressive complex 2, PRC2, RE-IIBP, SET, SET domain histone lysine methyltransferase, SETDB1, TXR1, vSET, WHSC1/MMSET isoform RE-IIBP

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.356 [histone H3]-lysine27 N-trimethyltransferase

Application

Application on EC 2.1.1.356 - [histone H3]-lysine27 N-trimethyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
-
three-dimensional solution structure of vSET bound to S-adenosyl-L-homocysteine and a histone H3 peptide containing mono-methylated lysine 27, only invariant active site residue tyrosine 105 in vSET facilitates methyl transfer from S-adenosyl-L-homocysteine to the substrate lysine by aligning intermolecular interactions in the lysine access channel of the enzyme
synthesis
expression of NSDs via tagging with a human influenza hemagglutinin tag greatly improves the quality of the recombinant NSDs, resulting in more than 95% pure, stable, and active NSD-hemagglutinins, with an increase in production yield up to 22.4fold and up to 6.25 mg/l from LB Escherichia coli culture, and without further purification