1.14.19.29: sphingolipid 8-(E/Z)-desaturase
This is an abbreviated version!
For detailed information about sphingolipid 8-(E/Z)-desaturase, go to the full flat file.
Reaction
+ 2 ferrocytochrome b5 + + 2 H+ = + 2 ferricytochrome b5 + 2 H2O
Synonyms
8 fatty acid desaturase, 8-sphingolipid desaturase, D8A, D8B, D8C, D8D, DELTA8 Des, Delta8 sphingolipid desaturase, DELTA8(E,Z)-sphingolipid desaturase, Delta8-fatty-acid desaturase 1, Delta8-fatty-acid desaturase 2, DELTA8-sphingolipid desaturase, Delta8-sphingolipid desaturase 1, Delta8-sphingolipid desaturase 2, Delta8-sphingolipid desaturase 3, DELTA8-sphingolipid-desaturase, DES8, DXDES, LCB DELTA8 desaturase, PtD8A, PtD8B, PtD8C, SLD, SLD1, SLD2, sphingoid long-chain base DELTA8 desaturase, sphingolipid DELTA8-desaturase
ECTree
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Engineering
Engineering on EC 1.14.19.29 - sphingolipid 8-(E/Z)-desaturase
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F59R
the mutant shows severely reduced activity compared to the wild type enzyme
L369A
the mutant shows severely reduced activity compared to the wild type enzyme
Q372H
the mutant shows severely reduced activity compared to the wild type enzyme
W190A
the mutant shows severely reduced activity compared to the wild type enzyme
W345A
the mutant shows severely reduced activity compared to the wild type enzyme