1.14.14.32: 17alpha-hydroxyprogesterone deacetylase

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For detailed information about 17alpha-hydroxyprogesterone deacetylase, go to the full flat file.

Reaction

Synonyms

17,20 lyase, 17-20 lyase, 17-alpha-hydroxylase/C17-20 lyase, 17-hydroxylase/C17,20-lyase, 17alpha-hydroxylase, 17alpha-hydroxylase-C(17,20)-lyase, 17alpha-hydroxylase-C17,20-lyase, 17alpha-hydroxylase/17,20 lyase, 17alpha-hydroxylase/17,20-lyase, 17alpha-hydroxylase/17,20-lyase cytochrome P450, 17alpha-hydroxylase/C(17,20)-lyase, 17alpha-hydroxylase/C17,20-lyase, 17alpha-hydroxyprogesterone aldolase, 17alpha-hydroxyprogesterone aldolase/17,20-lyase, 17alpha-lyase, Adrenal 17,20-lyase, aldolase, 17alpha-hydroxyprogesterone, C-17,20 lyase, C-17/C-20 lyase, C17(20) lyase, C17,20 lyase, C17,20-lyase, CYP17, CYP17A1, cytochrome P450 17, cytochrome P450 17A1, cytochrome P450 17alpha-hydroxylase/17,20-lyase, cytochrome p450 17alpha-hydroxylase/C(17,20)-lyase, cytochrome P450c17, EC 4.1.2.30, P-45017alpha, P450 17A1, P45017alpha, P450c17, P450c17-I, steroid 17alphahydroxylase/17,20-lyase, Steroid C17(20) lyase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.32 17alpha-hydroxyprogesterone deacetylase

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Results	in table
19	Activating Compound
818	AA Sequence
10	Application
1	CAS Registry Number
20	Cloned(Commentary)
7	Cofactor
1	Crystallization (Commentary)
3627	Disease/ Diagnostics
5	Expression
11	General Information
84	IC50 Value
170	Inhibitors
11	kcat/KM [mM/s]
10	Ki Value [mM]
20	KM Value [mM]
38	Localization
3	Molecular Weight [Da]
59	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
207	Organism
7	Pathway
26	PDB ID
2	pH Optimum
2	Posttranslational Modification
32	Protein Variants
3	Reaction
9	Reaction Type
67	Reference
84	Source Tissue
15	Specific Activity [micromol/min/mg]
117	Substrates and Products (Substrate)
2	Subunits
109	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
13	Turnover Number [1/s]

Synonyms

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Synonyms on EC 1.14.14.32 - 17alpha-hydroxyprogesterone deacetylase

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

17,20 lyase

2 entries

17-20 lyase

Homo sapiens

-

-

665842

17-alpha-hydroxylase/C17-20 lyase

Homo sapiens

-

-

715857

17-hydroxylase/C17,20-lyase

Homo sapiens

-

-

695150

17alpha-hydroxylase

Homo sapiens

P05093

-

734569

17alpha-hydroxylase-C(17,20)-lyase

Rattus norvegicus

-

-

695147

17alpha-hydroxylase-C17,20-lyase

Rattus norvegicus

-

-

706775, 713518

17alpha-hydroxylase/17,20 lyase

Homo sapiens

-

-

694117, 714275

17alpha-hydroxylase/17,20-lyase

4 entries

17alpha-hydroxylase/17,20-lyase cytochrome P450

Equus sp.

-

-

706819

17alpha-hydroxylase/C(17,20)-lyase

Rattus norvegicus

-

-

706778

17alpha-hydroxylase/C17,20-lyase

Rattus norvegicus

-

-

706778

17alpha-hydroxyprogesterone aldolase

Homo sapiens

-

-

690654

17alpha-hydroxyprogesterone aldolase/17,20-lyase

Homo sapiens

-

-

690654

17alpha-lyase

Homo sapiens

-

-

714275

Adrenal 17,20-lyase

-

-

-

-

aldolase, 17alpha-hydroxyprogesterone

-

-

-

-

C-17,20 lyase

-

-

-

-

C-17/C-20 lyase

-

-

-

-

C17(20) lyase

-

-

-

-

C17,20 lyase

Homo sapiens

-

-

680978

C17,20-lyase

2 entries

CYP17

17 entries

CYP17A1

5 entries

cytochrome P450 17

2 entries

cytochrome P450 17A1

Homo sapiens

P05093

-

734569, 737726

cytochrome P450 17alpha-hydroxylase/17,20-lyase

3 entries

cytochrome p450 17alpha-hydroxylase/C(17,20)-lyase

2 entries

cytochrome P450c17

2 entries

EC 4.1.2.30

-

-

formerly

-

P-45017alpha

Rattus norvegicus

-

-

702581

P450 17A1

Homo sapiens

P05093

-

745365

P45017alpha

Rattus norvegicus

-

-

693885, 695147, 706778

P450c17

8 entries

P450c17-I

Cynoglossus semilaevis

B2D2I4

-

703775

steroid 17alphahydroxylase/17,20-lyase

Homo sapiens

P05093

-

714352

Steroid C17(20) lyase

-

-

-

-

17,20 lyase

-

-

-

-

17,20 lyase

Rattus norvegicus

-

-

702581

17alpha-hydroxylase/17,20-lyase

Cynoglossus semilaevis

B2D2I4

-

703775

17alpha-hydroxylase/17,20-lyase

Homo sapiens

-

-

693347, 693809, 694115, 703945, 705509, 735283

17alpha-hydroxylase/17,20-lyase

Macaca mulatta

-

-

692093

17alpha-hydroxylase/17,20-lyase

Rattus norvegicus

-

-

693885, 702581, 706689

C17,20-lyase

Dicentrarchus labrax

-

-

677795

C17,20-lyase

Rattus norvegicus

-

-

706775, 713129

CYP17

Bison bison

-

-

714352

CYP17

Bos taurus

-

-

714352

CYP17

Capra hircus

-

-

714352

CYP17

Cavia porcellus

-

-

714352

CYP17

Dicentrarchus labrax

-

-

677795

CYP17

Equus caballus

-

-

714352

CYP17

Felis catus

-

-

714352

CYP17

Homo sapiens

-

-

665842, 690654, 693809, 694115, 694117, 695150, 714275, 715857, 738346

CYP17

Homo sapiens

-

catalyzes both steroid 17-hydroxylation and C17,20 lyase reactions

680978

CYP17

Homo sapiens

P05093

-

714352, 728827

CYP17

Mus musculus

-

-

705402, 714352

CYP17

Mus musculus C57BL/6

-

-

-

CYP17

Ovis aries

-

-

714352

CYP17

Pan troglodytes

-

-

714352

CYP17

Papio sp.

-

-

714352

CYP17

Rattus norvegicus

-

-

706689, 714352

CYP17

Sus scrofa

-

-

714352, 728827

CYP17A1

Cynoglossus semilaevis

B2D2I4

-

703775

CYP17A1

Homo sapiens

-

-

703945, 705509, 714275, 726886, 735283

CYP17A1

Homo sapiens

P05093

-

714352, 734569

CYP17A1

Homo sapiens

P05093

isoform

714352

CYP17A1

Spermophilus dauricus

-

-

705389

cytochrome P450 17

Homo sapiens

P05093

-

728827

cytochrome P450 17

Sus scrofa

-

-

728827

cytochrome P450 17alpha-hydroxylase/17,20-lyase

Mus musculus

-

-

705402

cytochrome P450 17alpha-hydroxylase/17,20-lyase

Mus musculus C57BL/6

-

-

-

cytochrome P450 17alpha-hydroxylase/17,20-lyase

Spermophilus dauricus

-

-

705389

cytochrome p450 17alpha-hydroxylase/C(17,20)-lyase

Rattus norvegicus

-

-

715984

cytochrome p450 17alpha-hydroxylase/C(17,20)-lyase

Rattus norvegicus Wistar

-

-

-

cytochrome P450c17

Homo sapiens

-

-

690654, 693809

cytochrome P450c17

Homo sapiens

P05093

-

739432

P450c17

Dicentrarchus labrax

-

-

677795

P450c17

Equus sp.

-

-

706819

P450c17

Homo sapiens

-

-

690654, 693347, 703945, 705509, 714275

P450c17

Homo sapiens

P05093

-

734569

P450c17

Macaca mulatta

-

-

692093

P450c17

Rattus norvegicus

-

-

715984

P450c17

Rattus norvegicus Wistar

-

-

-

P450c17

Spermophilus dauricus

-

-

705389