1.14.14.32: 17alpha-hydroxyprogesterone deacetylase

This is an abbreviated version!
For detailed information about 17alpha-hydroxyprogesterone deacetylase, go to the full flat file.

Reaction

Synonyms

17,20 lyase, 17-20 lyase, 17-alpha-hydroxylase/C17-20 lyase, 17-hydroxylase/C17,20-lyase, 17alpha-hydroxylase, 17alpha-hydroxylase-C(17,20)-lyase, 17alpha-hydroxylase-C17,20-lyase, 17alpha-hydroxylase/17,20 lyase, 17alpha-hydroxylase/17,20-lyase, 17alpha-hydroxylase/17,20-lyase cytochrome P450, 17alpha-hydroxylase/C(17,20)-lyase, 17alpha-hydroxylase/C17,20-lyase, 17alpha-hydroxyprogesterone aldolase, 17alpha-hydroxyprogesterone aldolase/17,20-lyase, 17alpha-lyase, Adrenal 17,20-lyase, aldolase, 17alpha-hydroxyprogesterone, C-17,20 lyase, C-17/C-20 lyase, C17(20) lyase, C17,20 lyase, C17,20-lyase, CYP17, CYP17A1, cytochrome P450 17, cytochrome P450 17A1, cytochrome P450 17alpha-hydroxylase/17,20-lyase, cytochrome p450 17alpha-hydroxylase/C(17,20)-lyase, cytochrome P450c17, EC 4.1.2.30, P-45017alpha, P450 17A1, P45017alpha, P450c17, P450c17-I, steroid 17alphahydroxylase/17,20-lyase, Steroid C17(20) lyase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.32 17alpha-hydroxyprogesterone deacetylase

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Results	in table
19	Activating Compound
818	AA Sequence
10	Application
1	CAS Registry Number
20	Cloned(Commentary)
7	Cofactor
1	Crystallization (Commentary)
3627	Disease/ Diagnostics
5	Expression
11	General Information
84	IC50 Value
170	Inhibitors
11	kcat/KM [mM/s]
10	Ki Value [mM]
20	KM Value [mM]
38	Localization
3	Molecular Weight [Da]
59	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
207	Organism
7	Pathway
26	PDB ID
2	pH Optimum
2	Posttranslational Modification
32	Protein Variants
3	Reaction
9	Reaction Type
67	Reference
84	Source Tissue
15	Specific Activity [micromol/min/mg]
117	Substrates and Products (Substrate)
2	Subunits
109	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
13	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.14.14.32 - 17alpha-hydroxyprogesterone deacetylase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

cytochrome b5

16 entries

-

P450 oxidoreductase

Homo sapiens

-

-

693347

-

PD98059

Homo sapiens

-

inhibitor of the MEK/ERK pathway. Treatment of cells with PD98059 (10 mM) at 24 and 48 h results in significant increases in the protein levels of CYP17. Production of androstenedione and estradiol significantly increases after treatment with PD98059

738346

additional information

Homo sapiens

-

serine phosphorylation of P450c17

693347

-

cytochrome b5

Bison bison

-

plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17. Rat cytochrome b5 stimulates the 17,20-lyase activity of bovine CYP17A1 by a factor of 4-5

714352

-

cytochrome b5

Bos taurus

-

plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17. Rat cytochrome b5 stimulates the 17,20-lyase activity of bovine CYP17A1 by a factor of 4-5

714352

-

cytochrome b5

Capra hircus

-

plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17. Rat cytochrome b5 stimulates the 17,20-lyase activity of bovine CYP17A1 by a factor of 4-5

714352

-

cytochrome b5

Cavia porcellus

-

plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17

714352

-

cytochrome b5

Equus caballus

-

plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17

714352

-

cytochrome b5

Felis catus

-

plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17

714352

-

cytochrome b5

Homo sapiens

-

-

693347

-

cytochrome b5

Homo sapiens

P05093

plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17. Rat cytochrome b5 stimulates the 17,20-lyase activity of human CYP17A1 by a factor of 5. The H67A mutant of cytochrome b5 and Zn-substituted b5 are both unable to bind heme and therefore fail to stimulate the catalytic activity of CYP17

714352

-

cytochrome b5

Homo sapiens

P05093

presence of cytochrome b5 markedly stimulates the 17,20-lyase reaction, with little effect on 17-hydroxylation. For the 17-hydroxylase reaction, progesterone oxidation is the most tightly coupled (about 50%) and negligibly changed upon addition of b5. For the 17,20-lyase reactions, b5 markedly increases product formation and coupling in parallel with all substrates, from 6% to 44% with the major substrate 17-hydroxypregnenolone

737726

-

cytochrome b5

Macaca mulatta

-

-

692093

-

cytochrome b5

Mus musculus

-

plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17

714352

-

cytochrome b5

Ovis aries

-

plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17. Rat cytochrome b5 stimulates the 17,20-lyase activity of bovine CYP17A1 by a factor of 4-5

714352

-

cytochrome b5

Pan troglodytes

-

plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17

714352

-

cytochrome b5

Papio sp.

-

plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17

714352

-

cytochrome b5

Rattus norvegicus

-

plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17

714352

-

cytochrome b5

Sus scrofa

-

plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17

714352

-