1.14.14.163: (S)-1-hydroxy-N-methylcanadine 13-hydroxylase
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For detailed information about (S)-1-hydroxy-N-methylcanadine 13-hydroxylase, go to the full flat file.
Reaction
Synonyms
1-hydroxy-N-methylcanadine 13-hydroxylase, CYP82X2
ECTree
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Application
Application on EC 1.14.14.163 - (S)-1-hydroxy-N-methylcanadine 13-hydroxylase
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synthesis
de novo production of noscapine in Saccharomyces cerevisiae, through the reconstruction of a biosynthetic pathway comprising over 30 enzymes from plants, bacteria, mammals, and yeast itself, including 7 plant endoplasmic reticulum (ER)-localized enzymes. Optimization directed to tuning expression of pathway enzymes, host endogenous metabolic pathways, and fermentation conditions led to an over 18,000-fold improvement from initial noscapine titers to 2.2 mg/l
synthesis
reconstitution of the noscapine gene cluster in Saccharomyces cerevisiae to achieve the microbial production of noscapine and related pathway intermediates