1.14.14.106: taxane 13alpha-hydroxylase

This is an abbreviated version!
For detailed information about taxane 13alpha-hydroxylase, go to the full flat file.

Reaction

Synonyms

cytochrome P450 taxoid 13alpha-hydroxylase, EC 1.14.13.77, taxoid 13alpha-hydroxylase, THY13a

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.106 taxane 13alpha-hydroxylase

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Results	in table
20	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
2	Cofactor
4	KM Value [mM]
3	Localization
1	Metals/Ions
2	Natural Substrates/ Products (Substrates)
4	Organism
6	Pathway
4	pH Optimum
1	pH Range
1	Purification (Commentary)
1	Reaction
3	Reaction Type
4	Reference
2	Source Tissue
1	Specific Activity [micromol/min/mg]
8	Substrates and Products (Substrate)
5	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

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Reference on EC 1.14.14.106 - taxane 13alpha-hydroxylase

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440248

Wheeler, A.L.; Long, R.M.; Ketchum, R.E.B.; Rithner, C.D.; Williams, R.M.; Croteau, R.

Taxol biosynthesis: differential transformations of taxadien-5alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells

Arch. Biochem. Biophys.

390

265-278

2001

Taxus cuspidata

11396929

440249

Jennewein, S.; Rithner, C.D.; Williams, R.M.; Croteau, R.B.

Taxol biosynthesis: taxane 13alpha-hydroxylase is a cytochrome P450-dependent monooxygenase

Proc. Natl. Acad. Sci. USA

13595-13600

2001

Taxus cuspidata (Q8W4T9)

11707604

672699

Jennewein, S.; Park, H.; DeJong, J.M.; Long, R.M.; Bollon, A.P.; Croteau, R.B.

Coexpression in yeast of Taxus cytochrome P450 reductase with cytochrome P450 oxygenases involved in taxol biosynthesis

Biotechnol. Bioeng.

588-598

2005

Taxus cuspidata

15672381

672704

DeJong, J.H.; Liu, Y.; Bollon, A.P.; Long, R.M.; Jennewein, S.; Williams, D.; Croteau, R.B.

Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae

Biotechnol. Bioeng.

212-224

2006

Taxus sp.

16161138