EC Number |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
---|
2.3.1.286 | Acidosis |
25085245 |
The SIRT1/HIF2? axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy. |
therapeutic application unassigned |
4 0 |
2.3.1.286 | Acquired Immunodeficiency Syndrome |
22443029 |
New clinical findings on the longevity gene in disease, health, & longevity: Sirtuin 1 often decreases with advanced age & serious diseases in most parts of the human body, while relatively high & constant Sirtuin 1 regardless of age was first found in the hippocampus of supercentenarians. |
causal interaction diagnostic usage unassigned |
2 2 0 |
2.3.1.286 | Acquired Immunodeficiency Syndrome |
28943955 |
p53 inhibits the upregulation of sirtuin 1 expression induced by c-Myc. |
causal interaction diagnostic usage ongoing research unassigned |
3 1 2 0 |
2.3.1.286 | Acute Coronary Syndrome |
25342474 |
Association between the SIRT1 mRNA Expression and Acute Coronary Syndrome. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 3 4 1 |
2.3.1.286 | Acute Kidney Injury |
20139070 |
Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function. |
causal interaction ongoing research therapeutic application unassigned |
2 4 2 0 |
2.3.1.286 | Acute Kidney Injury |
21416250 |
Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney. |
causal interaction ongoing research therapeutic application unassigned |
2 1 1 0 |
2.3.1.286 | Acute Kidney Injury |
23302720 |
The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury. |
causal interaction ongoing research therapeutic application unassigned |
2 3 2 0 |
2.3.1.286 | Acute Kidney Injury |
24896770 |
Sirt1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury. |
causal interaction ongoing research therapeutic application unassigned |
4 4 2 0 |
2.3.1.286 | Acute Kidney Injury |
25386563 |
Renal protective effect of sirtuin 1. |
causal interaction ongoing research therapeutic application unassigned |
3 2 1 0 |
2.3.1.286 | Acute Kidney Injury |
25607838 |
Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury. |
unassigned |
0 |