EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   2.1.1.294 | Hepatitis C |
12767472 |
Canonical 3'-deoxyribonucleotides as a chain terminator for HCV NS5B RNA-dependent RNA polymerase. |
causal interaction
therapeutic application
unassigned |
1
1
0 |
| 2.1.1.294 | Infections |
22664235 |
Understanding the molecular mechanism of sequence dependent tenofovir removal by HIV-1 reverse transcriptase: differences in primer binding site versus polypurine tract. |
causal interaction
therapeutic application
unassigned |
3
3
0 |
| 2.1.1.294 | Influenza, Human |
34237555 |
The mechanism of action of T-705 as a unique delayed chain terminator on influenza viral polymerase transcription. |
therapeutic application
unassigned |
3
0 |
| 2.1.1.294 | Leukemia |
17320040 |
Presence of the anti-leukemic nucleotide analog, 2-chloro-2'-deoxyadenosine-5'-monophosphate, in a promoter sequence alters DNA binding of TATA-binding protein (TBP). |
therapeutic application
unassigned |
3
0 |
| 2.1.1.294 | Leukemia, Hairy Cell |
17320040 |
Presence of the anti-leukemic nucleotide analog, 2-chloro-2'-deoxyadenosine-5'-monophosphate, in a promoter sequence alters DNA binding of TATA-binding protein (TBP). |
therapeutic application
unassigned |
3
0 |
| 2.1.1.294 | Melanoma |
11502887 |
Antitumor activity of 2',3'-dideoxycytidine nucleotide analog against tumors up-regulating DNA polymerase beta. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
3
3
4 |
| 2.1.1.294 | Muscular Diseases |
7572071 |
Early features of zidovudine-associated myopathy: histopathological findings and clinical correlations. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 2.1.1.294 | Neoplasms |
11249589 |
Tezacitabine Hoechst Marion Roussel. |
causal interaction
therapeutic application
unassigned |
2
4
0 |
| 2.1.1.294 | Neoplasms |
11502887 |
Antitumor activity of 2',3'-dideoxycytidine nucleotide analog against tumors up-regulating DNA polymerase beta. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
3
3
4 |
| 2.1.1.294 | Neoplasms |
32523988 |
Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication. |
therapeutic application
unassigned |
4
0 |
