EC Number   |
General Information |
Reference |
|---|
    2.3.3.16 | malfunction |
citrate synthase mutants exhibit altered colony morphology with enhanced pigmentation and reduced colony size and enter stationary phase early than the wild type enzyme |
-, 736830 |
| 2.3.3.16 | metabolism |
recombinant wild-type CS has no detectable acetylation. Acetylation of lysine residues does not result in significantly different activities with that of the wild-type, except for residues K283 and K295. Acetylation at K283 increases the activity by nearly twofold, while acetylation at K295 decreased the activity by about 10fold. CS can be acetylated by acetyl-phosphate chemically, and be deacetylated by the CobB deacetylase |
756709 |
| 2.3.3.16 | metabolism |
the enzyme is involved in the methylcitric acid cycle |
-, 747131 |
| 2.3.3.16 | metabolism |
the enzyme is part of the tricarboxylic acid cycle |
-, 736830 |
| 2.3.3.16 | physiological function |
Desulfurella acetivorans is capable of both acetate oxidation and autotrophic carbon fixation, with the tricarboxylic acid cycle operating either in the oxidative or reductive direction, respectively. Under autotrophic conditions, the enzyme citrate synthase cleaves citrate adenosine triphosphate-independently into acetyl-coenzyme A and oxaloacetate |
-, 758465 |
| 2.3.3.16 | physiological function |
enzymatic activities of citrate synthase and isocitrate dehydrogenase IDH2 are significantly reduced in methyl 4 phenylpyridinium treatment cells, while protein acetylation of citrate synthase and IDH2 increase. Overexpressed sirtuin SIRT3 partially reverses at least, the decline of citrate synthase activity and the increase of citrate synthase protein acetylation |
755951 |
| 2.3.3.16 | physiological function |
enzyme overexpression improves plant tolerance to iron stress in transgenic Arabidopsis, but also leads to increased fresh weight, root length, citrate synthase activity, and contents of chlorophyll, citrate acid and iron, especially when dealt with iron stress |
737011 |
| 2.3.3.16 | physiological function |
expression in Arabidopsis thaliana improves Fe stress tolerance and leads to increased fresh weight, root length, CS activity, and increased contents of chlorophyll, citrate acid, Fe and Zn, especially when dealt with Fe stress. Ectopic expression of CS3 results in abnormal flowers in transgenic Arabidopsis thaliana |
757999 |
| 2.3.3.16 | physiological function |
loss of CitA promotes the accumulation of active CtrA, an essential cell cycle transcriptional regulator that maintains cells in G1-phase, provided that the (p)ppGpp alarmone is present. The enzymatic activity of CitA is dispensable for CtrA control, and functional citrate synthase paralogs cannot replace CitA in promoting S-phase entry. CitA is able to complement an Escherichia coli GltA mutant |
-, 756582 |
| 2.3.3.16 | physiological function |
overexpression of CS1 in Escherichia coli enhances its growth under salt stress. Silencing of CS1 reduces fungal biomass at the middle stage of Puccinia striiformis infection, restricts fungal growth and development |
756609 |
