Literature summary for 2.3.3.16 extracted from

Cui, X.X.; Li, X.; Dong, S.Y.; Guo, Y.J.; Liu, T.; Wu, Y.C.
SIRT3 deacetylated and increased citrate synthase activity in PD model (2017), Biochem. Biophys. Res. Commun., 484, 767-773 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
additional information	SIRT3 deacetylates and activates citrate synhase activity	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
SH-SY5Y cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	enzymatic activities of citrate synthase and isocitrate dehydrogenase IDH2 are significantly reduced in methyl 4 phenylpyridinium treatment cells, while protein acetylation of citrate synthase and IDH2 increase. Overexpressed sirtuin SIRT3 partially reverses at least, the decline of citrate synthase activity and the increase of citrate synthase protein acetylation	Homo sapiens

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Release 2023.1 (January 2023)