EC Number |
Application |
Reference |
---|
1.14.14.18 | analysis |
glial HO-1 expression might be an early marker of non-hemorrhagic cell injury in the striatum, time course of induction, overview |
688506 |
1.14.14.18 | analysis |
live-cell activity assay based on heterologous coexpression in Escherichia coli of heme oxygenase and its mutants and a fluorescent biliverdin biosensor |
744356 |
1.14.14.18 | drug development |
heme oxygenase has cytoprotective properties and may play a role in several disease states, making it an interesting therapeutic target |
728211 |
1.14.14.18 | drug development |
the enzyme is a potential therapeutic target for antimicrobial drug development, computer-aided drug design and screening, overview |
681311 |
1.14.14.18 | medicine |
activity of heme oxygenase-1 interferes with porcine reproductive and respiratory syndrome virus PRRSV replication. The host cell antiviral effect depends on a heme oxygenase-1-biliverdin/bilrubin-nitric oxide-cGMP/PKG cascade |
744961 |
1.14.14.18 | medicine |
cells pretreated with curcumin at 37°C or during a programmed decrease in temperature exhibit increased resistance to oxidative stress-mediated injury, feasibility of modulating HO-1 expression during hydpothermic storage to confer tissues a better protection against damages characteristic of organ transplantation |
657748 |
1.14.14.18 | medicine |
chronic ethanol feeding induces 5-aminolevulinic acid synthase-1 (ALAS1) mRNA, cytosolic ALAS1 and mature ALAS1 protein levels, but not those of HO-1 in rat livers, which provides novel insights into the effects of chronic ethanol consumption on hepatic heme biosynthesis and porphyrias |
703698 |
1.14.14.18 | medicine |
Hmox1 protects against amyloid beta toxicity via production of CO. Protection does not arise from inhibition of apoptosis-associated K+ efflux, but rather by inhibition of AMP-dependent protein kinase activation |
744650 |
1.14.14.18 | medicine |
induction or exogenous overexpression of heme oxygenase HO-1 effectively inhibits Dengue virus DENV replication in DENV-infected Huh-7 cells. This antiviral is attenuated by inhibitor tin protoporphyrin. Biliverdin but not carbon monoxide and ferrous ions, mediates the HO-1-induced anti-DENV effect by non-competitively inhibiting DENV protease. HO-1 induction or its exogenous overexpression, rescues DENV-suppressed antiviral interferon response. HO-1 induction by cobalt protoporphyrin and andrographolide leads to a significant delay in the onset of disease and mortality, and virus load in the infected mice's brains |
746459 |
1.14.14.18 | medicine |
involved in the control of wound healing, heme-induced influx of leukocytes is highly elevated after inhibition of enzyme |
658343 |