Application | Comment | Organism |
---|---|---|
medicine | induction or exogenous overexpression of heme oxygenase HO-1 effectively inhibits Dengue virus DENV replication in DENV-infected Huh-7 cells. This antiviral is attenuated by inhibitor tin protoporphyrin. Biliverdin but not carbon monoxide and ferrous ions, mediates the HO-1-induced anti-DENV effect by non-competitively inhibiting DENV protease. HO-1 induction or its exogenous overexpression, rescues DENV-suppressed antiviral interferon response. HO-1 induction by cobalt protoporphyrin and andrographolide leads to a significant delay in the onset of disease and mortality, and virus load in the infected mice's brains | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96DI8 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
Hmox1 | - |
Homo sapiens |
Ho1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | HO-1 expression is induced by cobalt protoporphyrin and andrographolide | up |