Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
protoheme + 4 AH2 + 4 O2 | Staphylococcus aureus | - |
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | Staphylococcus aureus | - |
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | Staphylococcus aureus | - |
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | Staphylococcus aureus | - |
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | Staphylococcus aureus N315 | - |
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | Staphylococcus aureus N315 | - |
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | Staphylococcus aureus N315 | - |
15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | Staphylococcus aureus N315 | - |
5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | Q7A649 | isoform IsdG | - |
Staphylococcus aureus | Q7A827 | isoform IsdI | - |
Staphylococcus aureus N315 | Q7A649 | isoform IsdG | - |
Staphylococcus aureus N315 | Q7A827 | isoform IsdI | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
protoheme + 4 AH2 + 4 O2 | - |
Staphylococcus aureus | 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | - |
Staphylococcus aureus | 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | - |
Staphylococcus aureus | 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | in the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | - |
Staphylococcus aureus N315 | 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | - |
Staphylococcus aureus N315 | 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | in the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | - |
Staphylococcus aureus N315 | 15-oxo-beta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | - |
Staphylococcus aureus | 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | - |
Staphylococcus aureus | 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | - |
Staphylococcus aureus | 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | in the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | - |
Staphylococcus aureus N315 | 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | - |
Staphylococcus aureus N315 | 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | in the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? | |
protoheme + 4 AH2 + 4 O2 | - |
Staphylococcus aureus N315 | 5-oxo-delta-bilirubin + Fe2+ + CO + 4 A + 4 H2O | oxidoreductase IruO, gene name NWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid. The major heme degradation products are 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin, i.e. staphylobilins | ? |
General Information | Comment | Organism |
---|---|---|
physiological function | oxidoreductase IruO, gene name thatNWMN2274, is the likely in vivo reductant required for heme degradation by Staphylococcus aureus. In the presence of NADPH and IruO, either IsdI or IsdG degrade bound heme 10fold more rapidly than with the chemical reductant ascorbic acid | Staphylococcus aureus |